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Table 1 Dose acceptance and tolerability in cats subjected to a fortnightly dose escalation regimen of Lantharenol® (Study 1)

From: Tolerability and efficacy of the intestinal phosphate binder Lantharenol® in cats

Study group Dose of Lantharenol® (g/kg body weight) Lantharenol® content in feed original substance1 (g/kg) Lantharenol® content in complete feed2
(g/kg)
Daily consumption of Lantharenol® 3 (g/day) Days of administration No. of cats accepting/not accepting the feed Signs of intolerability
A 0 0 0 0 63 5/0 None
B 0 0 0 0 14 10/0 None
B 0.125 2.7 10.2 0.4 14 10/0 None
B 0.250 5.4 20.5 0.8 14 10/0 None
B 0.500 10.8 41.8 1.5 14 10/0 None
B 1.000 22.1 84.4 3.1 14 9/14 None
B 2.000 44.5 170.2 6.2 45 7/3 Vomiting
  1. The daily consumption, number of treatment days, number of cats accepting the feed and signs of intolerability observed were compared between a Lantharenol treated group (B; N = 10) and a negative control group (A; N = 5).
  2. 1 IAMS adult, rich in lamb, 24% dry matter
  3. 2 Complete feed is calculated by multiplying dry matter by the factor 1.12
  4. 3 Group means
  5. 4 One cat left 25% of its feed on 2 of 14 days
  6. 5 The highest dose of Lantharenol® was administered for 2 days, withdrawn for 2 days and then again given for 2 other days (re-challenge)