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Table 7 Immunophenotyping of CD3+/CD4+ and CD3+/CD8+ lymphocytes from chickens following inoculation with various plasmid constructs in Trial 2

From: Co-administration of avian influenza virus H5 plasmid DNA with chicken IL-15 and IL-18 enhanced chickens immune responses

DNAs inoculated groups Trial 2
Weeks post inoculation
CD3+/CD4+ CD3+/CD8+
Week 3 Week 6 Week 3 Week 6
Control 2.96 ± 0.52 7.25 ± 0.71 1.50 ± 0.28 3.58 ± 1.15
pDisplay 2.83 ± 0.34 7.42 ± 0.47 1.51 ± 0.66 3.28 ± 0.71
pDis/H5 6.56 ± 0.26* 8.86 ± 0.17* 2.52 ± 1.00 5.49 ± 1.15* a
pDis/H5 + pDis/IL-15 10.65 ± 0.59* a c 13.59 ± 1.15* a c 2.26 ± 0.38 3.53 ± 0.59
pDis/H5 + pDis/IL-18 8.42 ± 1.08* b 11.61 ± 0.61* b 2.12 ± 0.81 4.22 ± 1.21
  1. Each value represents the mean percentages of T cell sub-populations ± SD. The percentage of CD3+/CD4+ and CD3+/CD8+ T cells before inoculation are recorded as 2.64 ± 0.40 and 0.69 ± 0.24, respectively. Statistically significant differences (P < 0.05) are indicated by an asterisk (*), treated compared with untreated groups; a, pDis/H5 compared with pDis/H5 + pDis/IL-15; b, pDis/H5 compared with pDis/H5 + pDis/IL-18; c, pDis/H5 + pDis/IL-15 compared with pDis/H5 + pDis/IL-18.