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Table 6 Immunophenotyping of CD3+/CD4+ and CD3+/CD8+ lymphocytes from chickens following inoculation with various plasmid constructs in Trial 1

From: Co-administration of avian influenza virus H5 plasmid DNA with chicken IL-15 and IL-18 enhanced chickens immune responses

DNAs inoculated groups Trial 1
Weeks post inoculation
CD3+/CD4+ CD3+/CD8+
Week 2 Week 5 Week 2 Week 5
Control 2.23 ± 0.60 1.55 ± 0.26 0.91 ± 0.30 1.79 ± 0.58
pDisplay 2.55 ± 0.36 1.76 ± 0.14 1.16 ± 0.46 2.00 ± 0.35
pDis/H5 4.53 ± 0.33 * 4.19 ± 0.52* b 3.16 ± 0.56* a b 2.97 ± 0.55* a b
pDis/H5 + pDis/IL-15 6.98 ± 0.73* a c 6.28 ± 0.60* a c 1.94 ± 0.46* 1.64 ± 0.44
pDis/H5 + pDis/IL-18 4.46 ± 0.34* 3.45 ± 0.26* 2.31 ± 0.84* 1.95 ± 0.52
  1. Each value represents the mean percentages of T cell sub-populations ± SD. The percentage of CD3+/CD4+ and CD3+/CD8+ T cells before inoculation are recorded as 2.92 ± 0.40 and 0.52 ± 0.24, respectively. Statistically significant differences (P < 0.05) are indicated by an asterisk (*), treated compared with untreated groups; a, pDis/H5 compared with pDis/H5 + pDis/IL-15; b, pDis/H5 compared with pDis/H5 + pDis/IL-18; c, pDis/H5 + pDis/IL-15 compared with pDis/H5 + pDis/IL-18.