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Table 4 HI titer of serum samples obtained from chickens inoculated with various plasmid DNAs in Trial 1

From: Co-administration of avian influenza virus H5 plasmid DNA with chicken IL-15 and IL-18 enhanced chickens immune responses

DNAs- inoculated groups

  

HI titer

  

Weeks post inoculation

1

2*

3

4

5

6

7

Control

0

0

0

0

0

0

0

pDisplay

0

0

0

0

0

0

0

pDis/H5

1.52 ±1.38

1.62 ±1.43

1.87 ±1.43

2.30 ±1.34

3.25 ±1.60

4.92 ±1.60

6.50 ±1.40

pDis/H5 + pDis/IL-15

1.52 ±1.43

1.62 ±1.60

5.28 ±1.43a c

6.50 ±1.40a

13.00 ±1.40a c

10.56 ±1.43a c

12.13 ±1.43a c

pDis/H5 + pDis/IL-18

1.52 ±1.43

2.30 ±1.55

3.25 ±1.40b

4.92 ±1.40b

6.50 ±1.40b

6.50 ±1.40

6.50 ±1.40

  1. * Chickens were given a booster 2 weeks after initial inoculation. Statistically significant differences (P < 0.05) are indicated by a, pDis/H5 compared with pDis/H5 + pDis/IL-15; b, pDis/H5 compared with pDis/H5 + pDis/IL-18; c, pDis/H5 + pDis/IL-15 compared with pDis/H5 + pDis/IL-18.