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Table 2 Interaction summary of IL-4R with proteins (source of protein functions: Uniprot:

From: Comparison of genomic and proteomic data in recurrent airway obstruction affected horses using ingenuity pathway analysis®

Compartment Function Proteins
Extracellular Lung's innate immunity SERPINA1; surfactant protein D (SFTPD), transferrin (TF), complement factor B (CFB), complement component 3 (C3), complement component 5 (C5)
  Immunoglobulins immunoglobulin heavy constant gamma 1 (IGHG1), immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides (IGJ); immunoglobulin kappa constant (IGKC)
  Tumor Necrosis Factor family lymphotoxin beta (TNF superfamily, member 3) (LTB)
  Other proteins apolipoprotein A-I (APOA1), wingless-type MMTV integration site family member 7A (WNT7A), laminin beta 3 (LAMB3), Albumin (ALB) and secretoglobin, family 1A, member 1 (SCGB1A1) fibrinogen alpha chain (FGA); Plasminogen (PLG); serpin peptidase inhibitor clade C (antithrombin) member 1 (SERPINC1); von Willebrand factor (VWF); serpin peptidase inhibitor clade A (alpha-1 antiproteinase antitrypsin), member 1 (SERPINA1)
Cell membrane Immunoglobulin immunoglobulin heavy constant mu (IGHM)
  Immunoglobulins-receptor polymeric immunoglobulin receptor (PIGR)
  MHC class II major histocompatibility complex, class II, DQ beta 1 (HLA-DQB1)
  Adhesive interactions (e.g. granulocytes) integrin, alpha M (complement component 3 receptor 3 subunit) [ITGAM]
  Hemostasis thrombomodulin (THBD)
  Other proteins ATP-binding cassette, sub-family B (MDR/TAP), member 1 (ABCB1)
mucin 20, cell surface associated (MUC20);
platelet-derived growth factor receptor, alpha polypeptide (PDGFRA)
Cytoplasm Respiratory chain enzyme ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit (ATP5O);
  Induction of NF-kappa-B nucleotide-binding oligomerization domain containing 2 (NOD2)
  Protection from oxidative stress aldehyde dehydrogenase 7 family, member A1(ALDH7A1); glutathione S-transferase theta 1 (GSTT1)
  necessary for target cell lysis in cell-mediated immune responses granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) (GZMB)
  Other Proteins calponin 1, basic, smooth muscle (CNN1); serpin peptidase inhibitor, clade B (ovalbumin), member 10 (SERPINB10); uveal autoantigen with coiled-coil domains and ankyrin repeats (UACA); ribosomal protein S6 kinase, 90 kDa, polypeptide 4 (RPS6KA4); sorting nexin 9 (SNX9); heat shock 70 kDa protein 1-like (HSPA1L); actin, beta (ACTB); Glutaminase (GLS); ribosomal protein L23a (RPL23A); immediate early response 3 (IER3); thimet oligopeptidase 1 (THOP1); ferritin, light polypeptide (FTL);
coproporphyrinogen oxidase (CPOX)
Nucleus Tumor suppressors retinoblastoma-like 1 (p107) (RBL1); retinoblastoma 1 (RB1)
  Represses transcription of NF-kappa-B in response to TNF ribosomal protein S6 kinase, 90 kDa, polypeptide 5 (RPS6KA5); forkhead box P3 (FOXP3)
  Probable transcription factor forkhead box P3 (FOXP3)
  positive regulator of apoptosis serine/threonine kinase 17b (STK17B)
  Involved in DNA repair mechanism protein kinase, DNA-activated, catalytic polypeptide (PRKDC);
  Other Proteins bromodomain and PHD finger containing, 1 (BRPF1); heterogeneous nuclear ribonucleoprotein A3 (HNRNPA3); zinc finger and BTB domain containing 16 (ZBTB16)