Table 2 Interaction summary of IL-4R with proteins (source of protein functions: Uniprot: http://www.uniprot.org

Extracellular

Lung's innate immunity

SERPINA1; surfactant protein D (SFTPD), transferrin (TF), complement factor B (CFB), complement component 3 (C3), complement component 5 (C5)

Immunoglobulins

immunoglobulin heavy constant gamma 1 (IGHG1), immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides (IGJ); immunoglobulin kappa constant (IGKC)

Tumor Necrosis Factor family

lymphotoxin beta (TNF superfamily, member 3) (LTB)

Other proteins

apolipoprotein A-I (APOA1), wingless-type MMTV integration site family member 7A (WNT7A), laminin beta 3 (LAMB3), Albumin (ALB) and secretoglobin, family 1A, member 1 (SCGB1A1) fibrinogen alpha chain (FGA); Plasminogen (PLG); serpin peptidase inhibitor clade C (antithrombin) member 1 (SERPINC1); von Willebrand factor (VWF); serpin peptidase inhibitor clade A (alpha-1 antiproteinase antitrypsin), member 1 (SERPINA1)

Cell membrane

Immunoglobulin

immunoglobulin heavy constant mu (IGHM)

Immunoglobulins-receptor

polymeric immunoglobulin receptor (PIGR)

MHC class II

major histocompatibility complex, class II, DQ beta 1 (HLA-DQB1)

Adhesive interactions (e.g. granulocytes)

integrin, alpha M (complement component 3 receptor 3 subunit) [ITGAM]

Hemostasis

thrombomodulin (THBD)

Other proteins

ATP-binding cassette, sub-family B (MDR/TAP), member 1 (ABCB1)

mucin 20, cell surface associated (MUC20);

platelet-derived growth factor receptor, alpha polypeptide (PDGFRA)

Cytoplasm

Respiratory chain enzyme

ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit (ATP5O);

Induction of NF-kappa-B

nucleotide-binding oligomerization domain containing 2 (NOD2)

Protection from oxidative stress

aldehyde dehydrogenase 7 family, member A1(ALDH7A1); glutathione S-transferase theta 1 (GSTT1)

necessary for target cell lysis in cell-mediated immune responses

granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) (GZMB)

Other Proteins

calponin 1, basic, smooth muscle (CNN1); serpin peptidase inhibitor, clade B (ovalbumin), member 10 (SERPINB10); uveal autoantigen with coiled-coil domains and ankyrin repeats (UACA); ribosomal protein S6 kinase, 90 kDa, polypeptide 4 (RPS6KA4); sorting nexin 9 (SNX9); heat shock 70 kDa protein 1-like (HSPA1L); actin, beta (ACTB); Glutaminase (GLS); ribosomal protein L23a (RPL23A); immediate early response 3 (IER3); thimet oligopeptidase 1 (THOP1); ferritin, light polypeptide (FTL);

coproporphyrinogen oxidase (CPOX)

Nucleus

Tumor suppressors

retinoblastoma-like 1 (p107) (RBL1); retinoblastoma 1 (RB1)

Represses transcription of NF-kappa-B in response to TNF

ribosomal protein S6 kinase, 90 kDa, polypeptide 5 (RPS6KA5); forkhead box P3 (FOXP3)

Probable transcription factor

forkhead box P3 (FOXP3)

positive regulator of apoptosis

serine/threonine kinase 17b (STK17B)

Involved in DNA repair mechanism

protein kinase, DNA-activated, catalytic polypeptide (PRKDC);

Other Proteins

bromodomain and PHD finger containing, 1 (BRPF1); heterogeneous nuclear ribonucleoprotein A3 (HNRNPA3); zinc finger and BTB domain containing 16 (ZBTB16)