Table 1 Indirect interactions between genes IL-4R, IL-21R, CCL24, IL-27 and proteins
Gene, (abbreviation) and [number of interactions] | Indirect Interactions | Connecting proteins |
|---|---|---|
interleukin 4 receptor (IL-4R) [56] | Downregulated in RAO: FGA; APOA1; PLG; SERPINC1; WNT7A; GNL1; VWF; LTB; PDGFRA; THBD; GSTT1; ABCB1; STK17B; CPOX; CLIP2; CNN1; RPL23A; BRPF1; RBL1; UACA; RPS6KA5; HSPA1L; IER3; ATP50; ZBTB16; SERPINB10; Upregulated in RAO: IGKC; CFB; LAMB3; C3; SERPINA1; C5; MUC20; ITGAM; IGHM; HLADQB1; RPS6KA4; SNX9; ACTB; NOD2; GLS; THOP1; FTL; ALD7H7A1; GZMB; IGJ; HNRNPA3; RB1; FOXP3; PRKDC; Controversial findings: TF; SFTPD; SCGB1A1; ALB; IGHG1; PIGR; | SIRPA; TNF; IFNG; IL-4; GNB2L1; PTEN |
interleukin 21 receptor (IL-21R) [33] | Downregulated in RAO:VWF; IL-4R; IER3; ZBTB16; APOA1; CLIP2;RPL23A; RBL1; FGA; HSPA1L; SERPINC1; ATP50, ABCB1; Upregulated in RAO: C5;SERPINA1; CFB; ITGAM; HNRNPA3; RB1; ACTB; NOD2; FOXP3; ALDH7A1; FTL; GLS; GZMB; THOP1; HLA-DQB1; ITGAM Controversial findings :ALB; SFTPD; PIGR; | IFNG; TNF; CD40LG |
chemokine (C-C motif) ligand 24 (CCL24) [18] | Downregulated in RAO:STK17B; IER3; IL-4-R; LTB; CPOX; Upregulated in RAO: C5; IGJ; C3; IGHM; GZMB; THOP1; RB1; PRKDC; FOXP3; Controversial findings : PIGR; SCGB1A1; IGHG1; | IL-4 |
interleukin 27 (IL-27) [3] | Upregulated in RAO: HLA-DQB1; C5; FOXP3 |