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Table 2 Echocardiographic parameters measured before (D0) and after (D6) administration of 5 mg/kg (Group 1) or 25 mg/kg (Group 2) of oral doxycycline BID during 5 consecutive days in 2 months-old healthy Belgian Blue calves.

From: Clinical evaluation of cardiac effects of experimental doxycycline overdosing in healthy calves

  Group 1 (n = 6) Group 2 (n = 6)  
  D0
Mean ± SD
D6
Mean ± SD
D0
Mean ± SD
D6
Mean ± SD
Group 1 vs Group 2
p
HR (beats/min) 108 ± 13 110 ± 10 83 ± 12 95 ± 27 NS
LVIDs (cm) 3.96 ± 0.42 3.65 ± 0.51 3.29 ± 0.61 3.40 ± 0.56 NS
LVIDd (cm) 5.67 ± 0.28 5.45 ± 0.46 4.91 ± 0.62 5.09 ± 0.64 NS
IVSs (cm) 1.86 ± 0.11 1.88 ± 0.10 1.84 ± 0.17 1.83 ± 0.17 NS
IVSd (cm) 1.11 ± 0.03 1.11 ± 0.10 1.12 ± 0.18 1.16 ± 0.14 NS
FS (%) 30.19 ± 6.74 33.22 ± 4.43 33.35 ± 6.25 33.40 ± 5.48 NS
% IVS 67.05 ± 6.74 69.91 ± 8.59 65.63 ± 20.28 58.33 ± 17.06 NS
EDV (cm3) 158.40 ± 17.90 145.50 ± 19.99 115.51 ± 9.24 125.65 ± 22.68 NS
ESV (cm3) 69.13 ± 17.20 57.72 ± 14.50 45.73 ± 12.27 49.08 ± 16.16 NS
SI (ml kg-1beat-1) 1.17 ± 0.27 1.01 ± 0.20 0.95 ± 0.14 1.04 ± 0.16 NS
CI (ml kg-1 min-1) 0.13 ± 0.04 0.11 ± 0.04 0.08 ± 0.03 0.10 ± 0.03 NS
EF 0.56 ± 0.09 0.61 ± 0.05 0.61 ± 0.06 0.61 ± 0.06 NS
  1. HR: heart rate; LVIDs and LVIDd: left ventricular internal diameter in systole and diastole; IVSs and IVSd: interventricular septum thickness in systole and diastole; FS: fractional shortening of the left ventricle; %IVS: fractional thickening of the interventricular septum; EDV: end diastolic volume; ESV: end systolic volume; SV: stroke volume; SI: stroke index; CI: cardiac index; EF: ejection fraction.