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Table 1 Blood analysis results before (D0) and after (D6) 5 days administration of 5 mg/kg (Group 1) or 25 mg/kg (Group 2) of oral doxycycline BID in 2 months-old healthy Belgian Blue calves.

From: Clinical evaluation of cardiac effects of experimental doxycycline overdosing in healthy calves

   Group 1 (n = 6) Group 2 (n = 6)  
  Reference
range
D0
Mean ± SD
D6
Mean ± SD
D0
Mean ± SD
D6
Mean ± SD
Group 1 vs Group 2
p
AST (IU/L) 70-130 77 ± 13 77 ± 16 62 ± 19 68 ± 23 NS
LDH (IU/L) 1691-2618 2464 ± 512 2578 ± 428 2031 ± 336 2169 ± 348 NS
CK (IU/L) 128-244 270 ± 257 306 ± 27 145 ± 37 191 ± 79 NS
Iso-CK MM (%)   55 ± 17 45 ± 21 39 ± 11 47 ± 16 NS
Iso-CK BB (%)   5 ± 2 4 ± 2 5 ± 2 3 ± 1 NS
Iso-CK MB (%)   3 ± 3 3 ± 2 3 ± 1 2 ± 1 NS
Iso-CK MT (%)   37 ± 14 49 ± 18 54 ± 12 49 ± 17 NS
  1. AST: aspartate aminotransferase; LDH: lactate dehydrogenase; CK: creatine kinase; Iso-CK MM: muscle creatine kinase isoenzyme; Iso-CK BB: brain creatine kinase isoenzyme; Iso-CK MB: heart creatine kinase isoenzyme; Iso-CK MT: mitochondrial creatine kinase isoenzyme; NS: not significant.