Parameter | FiO2 | -5 min | 15 min | 30 min | 60 min | 90 min | 120 min | 150 min | 180 min | +10 min | Stand + 30 min |
---|---|---|---|---|---|---|---|---|---|---|---|
CaO2 (mL/dL) | 50% | 17.9 ± 2.1 | 16.7 ± 0.5 | 16.4 ± 0.7 | 19.3 ± 0.3 | 18.7 ± 0.3 | 18.3 ± 0.7 | 17.4 ± 1.1 | 16.9 ± 1.0 | 14.4 ± 0.4 | 16.2 ± 0.6 |
 | >95% | 16.4 ± 0.7 | 17.0 ± 0.5 | 18.3 ± 1.0 | 19.4 ± 1.2 | 19.4 ± 0.6 | 19.1 ± 0.7 | 19.2 ± 1.1 | 18.6 ± 1.2 | 14.3 ± 0.8 | 15.4 ± 0.6 |
CvO2 (mL/dL) | 50% | 13.0 ± 1.7 | 13.1 ± 0.6 | 13.2 ± 0.5 | 16.9 ± 0.6 | 16.6 ± 0.3 | 15.5 ± 0.9 | 14.9 ± 1.5 | 14.1 ± 1.3 | 9.9 ± 0.7 | 10.2 ± 0.7 |
 | >95% | 11.3 ± 0.5 | 14.3 ± 0.5 | 15.1 ± 1.0 | 16.5 ± 1.4 | 16.4 ± 1.2 | 15.9 ± 1.3 | 15.4 ± 1.3 | 14.7 ± 1.3 | 9.7 ± 0.8 | 9.3 ± 1.2 |
O2ER (%) | 50% | 27 ± 4 | 22 ± 2 | 19 ± 3 | 12 ± 3 | 11 ± 1 | 15 ± 3 | 15 ± 4 | 17 ± 3 | 32 ± 3 | 37 ± 4 |
 | >95% | 31 ± 1 | 16 ± 2 | 18 ± 4 | 15 ± 3 | 16 ± 4 | 17 ± 5 | 20 ± 3 | 21 ± 3 | 32 ± 3 | 40 ± 6 |
VO2 (mL/kg bwt/min) | 50% | 2.9 ± 1 | 1.5 ± 0.2 | 1.4 ± 0.2 | 1.1 ± 0.2a | 1.1 ± 0.1a | 1.0 ± 0.1a | 0.9 ± 0.1a | 1.0 ± 0.1a | 1.4 ± 0.1 | 3.5 ± 0.5 |
 | >95% | 2.8 ± 0.2 | 1.0 ± 0.1a | 1.3 ± 0.2 | 1.4 ± 0.2 | 1.1 ± 0.2 | 1.2 ± 0.2 | 1.3 ± 0.1 | 1.3 ± 0.1 | 1.6 ± 0.1 | 4.0 ± 0.8 |
C(a-v)O2 (mL/dL) | 50% | 4.87 ± 0.79 | 3.61 ± 0.40 | 3.20 ± 0.59 | 2.34 ± 0.49 | 2.12 ± 0.29 | 2.77 ± 0.48 | 2.53 ± 0.56 | 2.73 ± 0.38 | 4.52 ± 0.28 | 5.93 ± 0.65 |
 | >95% | 5.12 ± 0.32 | 2.75 ± 0.40 | 3.28 ± 0.65 | 2.86 ± 0.49 | 3.00 ± 0.74 | 3.18 ± 0.84 | 3.75 ± 0.52 | 3.83 ± 0.46 | 4.61 ± 0.51 | 6.08 ± 0.80 |
PaO2-IO2 ratio | 50% | 0.64 ± 0.05 | 0.27 ± 0.03a | 0.28 ± 0.02a | 0.30 ± 0.02a | 0.29 ± 0.03a | 0.27 ± 0.03a | 0.23 ± 0.03a | 0.22 ± 0.03a | 0.30 ± 0.01a | 0.64 ± 0.02 |
 | >95% | 0.64 ± 0.03 | 0.41 ± 0.05 | 0.36 ± 0.05a | 0.41 ± 0.07 | 0.38 ± 0.06a | 0.35 ± 0.07a | 0.32 ± 0.07a | 0.32 ± 0.07a | 0.32 ± 0.02a | 0.55 ± 0.06 |
P(A-a)O2 (kPa) | 50% | 1.84 ± 1.09 | 27.51 ± 2.07a,b | 27.12 ± 1.00a,b | 26.52 ± 1.05a,b | 26.79 ± 1.29a,b | 27.85 ± 1.23a,b | 30.26 ± 1.60a,b | 29.81 ± 1.44a,b | 5.99 ± 0.67 | 0.99 ± 0.20 |
 | >95% | 1.20 ± 0.31 | 45.93 ± 3.90a,b | 51.07 ± 4.51a,b | 46.77 ± 5.97a,b | 49.22 ± 5.26a,b | 52.08 ± 6.38a,b | 54.36 ± 6.31a,b | 55.33 ± 6.48a,b | 5.74 ± 0.90 | 2.40 ± 1.04 |
DO2 (mL/kg bwt/min) | 50% | 10.82 ± 3.59 | 6.84 ± 0.60 | 7.44 ± 0.84 | 9.82 ± 0.85 | 9.91 ± 0.94 | 7.48 ± 1.07 | 6.71 ± 1.00 | 6.24 ± 0.61 | 4.62 ± 0.26a | 9.47 ± 0.78 |
 | >95% | 9.16 ± 1.00 | 6.26 ± 0.24 | 7.24 ± 0.49 | 9.55 ± 0.89 | 8.34 ± 1.19 | 7.91 ± 1.03 | 6.65 ± 0.50 | 6.47 ± 0.44 | 5.11 ± 0.41 | 10.20 ± 1.19 |
Qs/Qt (%) | 50% | 13 ± 2 | 28 ± 4 | 30 ± 5 | 39 ± 8a | 40 ± 6a | 36 ± 4 | 40 ± 4a | 40 ± 3a | 43 ± 4a | 9 ± 1 |
 | >95% | 9 ± 1 | 35 ± 4a | 36 ± 6a | 36 ± 4a | 38 ± 5a | 37 ± 4a | 33 ± 3a | 32 ± 3 | 38 ± 5a | 12 ± 2 |
Vd/Vt (%) | 50% | ----- | 11.9 ± 4.4 | 11.7 ± 1.3 | 17.6 ± 1.5 | 19.4 ± 2.6 | 19.4 ± 3.1 | 20.5 ± 2.4 | 27.2 ± 3.9c | ----- | ----- |
 | >95% | ----- | 13.6 ± 3.2 | 17.7 ± 1.9 | 16.4 ± 2.2 | 18.7 ± 3.8 | 23.4 ± 2.3 | 27.6 ± 2.3 | 29.2 ± 2.2c | ----- | ----- |