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Table 3 Oxygen variables from isoflurane-anesthetized horses (n = 5) breathing 50% or maximal oxygen concentrations

From: Effect of 50% and maximal inspired oxygen concentrations on respiratory variables in isoflurane-anesthetized horses

Parameter

FiO2

-5 min

15 min

30 min

60 min

90 min

120 min

150 min

180 min

+10 min

Stand + 30 min

CaO2 (mL/dL)

50%

17.9 ± 2.1

16.7 ± 0.5

16.4 ± 0.7

19.3 ± 0.3

18.7 ± 0.3

18.3 ± 0.7

17.4 ± 1.1

16.9 ± 1.0

14.4 ± 0.4

16.2 ± 0.6

 

>95%

16.4 ± 0.7

17.0 ± 0.5

18.3 ± 1.0

19.4 ± 1.2

19.4 ± 0.6

19.1 ± 0.7

19.2 ± 1.1

18.6 ± 1.2

14.3 ± 0.8

15.4 ± 0.6

CvO2 (mL/dL)

50%

13.0 ± 1.7

13.1 ± 0.6

13.2 ± 0.5

16.9 ± 0.6

16.6 ± 0.3

15.5 ± 0.9

14.9 ± 1.5

14.1 ± 1.3

9.9 ± 0.7

10.2 ± 0.7

 

>95%

11.3 ± 0.5

14.3 ± 0.5

15.1 ± 1.0

16.5 ± 1.4

16.4 ± 1.2

15.9 ± 1.3

15.4 ± 1.3

14.7 ± 1.3

9.7 ± 0.8

9.3 ± 1.2

O2ER (%)

50%

27 ± 4

22 ± 2

19 ± 3

12 ± 3

11 ± 1

15 ± 3

15 ± 4

17 ± 3

32 ± 3

37 ± 4

 

>95%

31 ± 1

16 ± 2

18 ± 4

15 ± 3

16 ± 4

17 ± 5

20 ± 3

21 ± 3

32 ± 3

40 ± 6

VO2 (mL/kg bwt/min)

50%

2.9 ± 1

1.5 ± 0.2

1.4 ± 0.2

1.1 ± 0.2a

1.1 ± 0.1a

1.0 ± 0.1a

0.9 ± 0.1a

1.0 ± 0.1a

1.4 ± 0.1

3.5 ± 0.5

 

>95%

2.8 ± 0.2

1.0 ± 0.1a

1.3 ± 0.2

1.4 ± 0.2

1.1 ± 0.2

1.2 ± 0.2

1.3 ± 0.1

1.3 ± 0.1

1.6 ± 0.1

4.0 ± 0.8

C(a-v)O2 (mL/dL)

50%

4.87 ± 0.79

3.61 ± 0.40

3.20 ± 0.59

2.34 ± 0.49

2.12 ± 0.29

2.77 ± 0.48

2.53 ± 0.56

2.73 ± 0.38

4.52 ± 0.28

5.93 ± 0.65

 

>95%

5.12 ± 0.32

2.75 ± 0.40

3.28 ± 0.65

2.86 ± 0.49

3.00 ± 0.74

3.18 ± 0.84

3.75 ± 0.52

3.83 ± 0.46

4.61 ± 0.51

6.08 ± 0.80

PaO2-IO2 ratio

50%

0.64 ± 0.05

0.27 ± 0.03a

0.28 ± 0.02a

0.30 ± 0.02a

0.29 ± 0.03a

0.27 ± 0.03a

0.23 ± 0.03a

0.22 ± 0.03a

0.30 ± 0.01a

0.64 ± 0.02

 

>95%

0.64 ± 0.03

0.41 ± 0.05

0.36 ± 0.05a

0.41 ± 0.07

0.38 ± 0.06a

0.35 ± 0.07a

0.32 ± 0.07a

0.32 ± 0.07a

0.32 ± 0.02a

0.55 ± 0.06

P(A-a)O2 (kPa)

50%

1.84 ± 1.09

27.51 ± 2.07a,b

27.12 ± 1.00a,b

26.52 ± 1.05a,b

26.79 ± 1.29a,b

27.85 ± 1.23a,b

30.26 ± 1.60a,b

29.81 ± 1.44a,b

5.99 ± 0.67

0.99 ± 0.20

 

>95%

1.20 ± 0.31

45.93 ± 3.90a,b

51.07 ± 4.51a,b

46.77 ± 5.97a,b

49.22 ± 5.26a,b

52.08 ± 6.38a,b

54.36 ± 6.31a,b

55.33 ± 6.48a,b

5.74 ± 0.90

2.40 ± 1.04

DO2 (mL/kg bwt/min)

50%

10.82 ± 3.59

6.84 ± 0.60

7.44 ± 0.84

9.82 ± 0.85

9.91 ± 0.94

7.48 ± 1.07

6.71 ± 1.00

6.24 ± 0.61

4.62 ± 0.26a

9.47 ± 0.78

 

>95%

9.16 ± 1.00

6.26 ± 0.24

7.24 ± 0.49

9.55 ± 0.89

8.34 ± 1.19

7.91 ± 1.03

6.65 ± 0.50

6.47 ± 0.44

5.11 ± 0.41

10.20 ± 1.19

Qs/Qt (%)

50%

13 ± 2

28 ± 4

30 ± 5

39 ± 8a

40 ± 6a

36 ± 4

40 ± 4a

40 ± 3a

43 ± 4a

9 ± 1

 

>95%

9 ± 1

35 ± 4a

36 ± 6a

36 ± 4a

38 ± 5a

37 ± 4a

33 ± 3a

32 ± 3

38 ± 5a

12 ± 2

Vd/Vt (%)

50%

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11.9 ± 4.4

11.7 ± 1.3

17.6 ± 1.5

19.4 ± 2.6

19.4 ± 3.1

20.5 ± 2.4

27.2 ± 3.9c

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>95%

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13.6 ± 3.2

17.7 ± 1.9

16.4 ± 2.2

18.7 ± 3.8

23.4 ± 2.3

27.6 ± 2.3

29.2 ± 2.2c

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  1. Data are presented as mean ± standard error of the mean. CaO2, arterial oxygen content; CvO2, venous oxygen content; O2ER, oxygen extraction ratio; VO2, oxygen consumption; C(a-v)O2, oxygen content difference; PaO2-IO2 ratio, arterial oxygen tension to inspired oxygen tension ratio; P(A-a)O2, alveolar arterial oxygen tension difference; DO2, oxygen delivery; Qs/Qt, shunt fraction; Vd/Vt, alveolar dead space. Time points: -5, 15, 30, 60, 90, 120, 150, and 180 represent min prior to and after induction of anesthesia; +10 min represents 10 min after disconnection from the anesthesia machine; and Stand +30 min represents 30 min after the horses stood in recovery.
  2. a Within a treatment, value is significantly different than the -5 min value for this variable.
  3. b Within this time point, value is significantly different than other treatment
  4. c With a treatment, value is significantly different from the 15 min value for this variable