Effect of 50% and maximal inspired oxygen concentrations on respiratory variables in isoflurane-anesthetized horses

Hubbell, John AE; Aarnes, Turi K; Bednarski, Richard M; Lerche, Phillip; Muir, William W

doi:10.1186/1746-6148-7-23

Table 1 Hemodynamic and patient variables from isoflurane-anesthetized horses (n = 5) breathing 50% or maximal oxygen concentrations

From: Effect of 50% and maximal inspired oxygen concentrations on respiratory variables in isoflurane-anesthetized horses

Parameter	FiO2	-5 min	15 min	30 min	60 min	90 min	120 min	150 min	180 min	+10 min	Stand + 30 min
HR (beats/min)	50%	35 ± 2	32 ± 1	39 ± 2	40 ± 3	46 ± 3	43 ± 2	39 ± 3	39 ± 3	38 ± 4	38 ± 2
	>95%	42 ± 6	35 ± 3	37 ± 3	39 ± 5	39 ± 3	42 ± 3	41 ± 4	43 ± 4	34 ± 4	45 ± 5
RR (breaths/min)	50%	26 ± 3	6 ± 0^a	5 ± 0^a	5 ± 0^a	4 ± 0^a	4 ± 0^a	4 ± 0^a	4 ± 0^a	12 ± 1^a	20 ± 5
	>95%	27 ± 5	6 ± 0^a	5 ± 0^a	5 ± 0^a	5 ± 0^a	5 ± 0^a	5 ± 0^a	5 ± 0^a	12 ± 4^a	17 ± 2
PIP (cmH₂0)	50%	-----	29 ± 4	30 ± 3	31 ± 3	31 ± 3	32 ± 3	32 ± 3	33 ± 3	-----	-----
	>95%	-----	30 ± 4	29 ± 3	31 ± 2	32 ± 3	31 ± 3	32 ± 3	31 ± 3	-----	-----
EtCO2 (kPa)	50%	-----	4.18 ± 0.21	4.08 ± 0.13	4.18 ± 0.13	4.42 ± 0.18	4.21 ± 0.04	4.05 ± 0.10	3.97 ± 0.11	-----	-----
	>95%	-----	3.92 ± 0.33	4.32 ± 0.30	4.47 ± 0. 62	4.34 ± 0.12	4.21 ± 0.09	4.03 ± 0.12	3.82 ± 0.12	-----	-----
SABP (mmHg)	50%	143 ± 9	109 ± 6^a	88 ± 5^a	107 ± 4^a	106 ± 3^a	105 ± 2^a	100 ± 1^a	104 ± 2^a	128 ± 5	176 ± 8^a
	>95%	147 ± 7	106 ± 8^a	95 ± 4^a	103 ± 6^a	103 ± 7^a	104 ± 6^a	105 ± 4^a	102 ± 5^a	129 ± 7	172 ± 10
MABP (mmHg)	50%	110 ± 3	82 ± 5^a	66 ± 4^a	80 ± 2^a	85 ± 1^a	84 ± 2^a	84 ± 3^a	85 ± 1^a	109 ± 4	138 ± 7^a
	>95%	112 ± 6	82 ± 9^a	69 ± 3^a	79 ± 5^a	80 ± 4^a	81 ± 4^a	84 ± 4^a	82 ± 2^a	106 ± 4	136 ± 6^a
DABP (mmHg)	50%	87 ± 5	69 ± 4	54 ± 3^a	68 ± 2	72 ± 3	73 ± 3	71 ± 4	76 ± 2	96 ± 3	123 ± 11^a
	>95%	93 ± 6	69 ± 8	58 ± 4^a	66 ± 4^a	67 ± 3^a	72 ± 4	73 ± 4	70 ± 3	97 ± 4	115 ± 6
MRAP (mmHg)	50%	14 ± 3	6 ± 2	9 ± 1	10 ± 2	9 ± 2	12 ± 1	12 ± 1	13 ± 2	24 ± 1	15 ± 3
	>95%	13 ± 2	10 ± 2	13 ± 1	12 ± 2	11 ± 2	12 ± 3	14 ± 3	14 ± 3	21 ± 4	14 ± 3
MPAP (mmHg)	50%	30 ± 4	14 ± 1	17 ± 0	20 ± 2	23 ± 2	24 ± 3	24 ± 2	23 ± 2	36 ± 2	32 ± 3
	>95%	31 ± 2	21 ± 5	23 ± 4	26 ± 5	26 ± 5	26 ± 5	26 ± 5	26 ± 5	34 ± 5	34 ± 4
Q (L/min)	50%	34.2 ± 5.6	25.4 ± 2.8	28.1 ± 3.4	31.5 ± 2.8	32.9 ± 3.8	25.2 ± 3.3	23.3 ± 2.4	22.7 ± 1.5	19.9 ± 1.4	36.5 ± 3.6
	>95%	34.2 ± 3.6	22.5 ± 1.1	24.2 ± 1.5	30.1 ± 1.9	26.1 ± 3.6	25.2 ± 3.1	21.1 ± 0.9	21.3 ± 0.9	21.8 ± 1.5	40.2 ± 3.9
CI (L/kg bwt/min)	50%	0.056 ± 0.010	0.041 ± 0.004	0.045 ± 0.005	0.051 ± 0.005	0.053 ± 0.005	0.041 ± 0.005	0.038 ± 0.004	0.037 ± 0.0002	0.032 ± 0.002	0.059 ± 0.006
	>95%	0.056 ± 0.005	0.037 ± 0.001	0.040 ± 0.003	0.049 ± 0.003	0.043 ± 0.006	0.041 ± 0.005	0.035 ± 0.001	0.035 ± 0.001	0.036 ± 0.002	0.066 ± 0.007
SVR (dyn sec cm^-5)	50%	248 ± 33	249 ± 34	172 ± 23	182 ± 13	195 ± 21	245 ± 33	258 ± 26	261 ± 22	347 ± 17	282 ± 36
	>95%	234 ± 13	256 ± 26	190 ± 25	182 ± 15	227 ± 35	227 ± 21	268 ± 14	256 ± 13	318 ± 24	251 ± 22

Data are presented as mean ± standard error of the mean. HR, heart rate; RR, respiratory rate; PIP, peak inspiratory pressure; EtCO₂, end-tidal CO₂; SABP, systolic arterial blood pressure; MABP, mean arterial blood pressure; DABP, diastolic arterial blood pressure; MRAP, mean right atrial pressure; MPAP, mean pulmonary artery pressure; Q, cardiac output; CI, cardiac index; SVR, systemic vascular resistance. Time points: -5, 15, 30, 60, 90, 120, 150, and 180 represent min prior to and after induction of anesthesia; +10 min represents 10 min after disconnection from the anesthesia machine; and Stand +30 min represents 30 min after the horses stood in recovery.
a Within a treatment, value is significantly different than the -5 min value for this variable.

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ISSN: 1746-6148

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