Relationship between clinical signs and postmortem test status in cattle experimentally infected with the bovine spongiform encephalopathy agent

Table 6 Relative frequency of clinical signs at observations over time post inoculation compared to control cattle

Study	1	1	1	1	2	2	2
Groups	100 g	1 g	1 g	100 g	4	3	2
Postmortem BSE diagnosis	Pos	Pos	Neg	Neg	Pos	Neg	Neg
*Behaviour*
Flank licking	↑↑↑			↑↑	↓↓↓	↓↓↓	↓↓↓
Unusual asymmetrical ear movements	↑↑↑				↑↑
Vocalisation	↑↑
Head toss	↑↑
Snorting	↑↑	↓↓↓
Nose licking	↑↑						↓↓↓
Grooming self		↑↑	↑↑
Apprehension		↑↑			↑↑↑
BSE series of events		↓↓↓			↑↑		↑
Grooming others			↑↑				↑↑
Standing idle & not approached			↓↓↓	↓↓↓	↑↑↑
Mounting				↑↑	↑↑↑	↑↑	↑↑↑
Sneezing					↑↑
Being mounted					↑
Head rubbing						↓↓↓
Nose wrinkling							↓↓↓
Coughing							↓↓↓
*Sensation*
Startle at movement including hand approach/clipboard test	↑↑↑	↑↑↑			↑↑↑
Hyperaesthesia	↑↑↑	↓↓			↑↑↑
Startle at movement	↑↑↑			↑	↑↑↑	↑↑↑
Startle at noise	↑↑				↑↑↑
Abnormal hand approach/clipboard test					↑↑
*Movement and posture*
Muscle fasciculations	↑↑		↑↑↑	↑↑
Tremor					↑↑
Abnormal head carriage							↓

Groups were compared with undosed controls (study 1) and saline-inoculated controls (study 2).
↑= greater/↓ = lower hazard rate than controls, with P<0.001 (three arrows), P = 0.001-0.01 (two arrows) and P>0.01 and <0.0125 (four comparisons) or <0.0167 (three comparisons) (one arrow). Blank cell: no significant difference.
Only signs that were significantly differently displayed compared to controls are listed.

ISSN: 1746-6148