Discriminatory PrPd immunohistochemistry. Classical Scrapie (a+b) and ovine BSE (c+d) are discriminated by using two antibodies linking at distinct epitopes of the prion protein. The core-binding MAb R145 shows intraneuronal immunolabeling in classical scrapie (a) and ovine BSE (c) while the n-terminal-binding MAb 12B2 only detects intraneuronal labeling in classical scrapie (b) whereas PrPd in ovine BSE remains undetected in the neurons. Two examples, one of a goat (ID 15355, e and f) and one of a sheep (ID S1RS, g and h) exemplify the findings in the cases under investigation. For the results of the complete sample set refer to table 4.