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Table 3 Vacuolation scores for each neuroanatomical area in each group of AHQ/AHQ cases

From: The natural atypical scrapie phenotype is preserved on experimental transmission and sub-passage in PRNP homologous sheep

  

Mean vacuolation score (± SD)

Area Code

Neuroanatomical area

Atypical Primary challenge

Atypical Sub-passage

Classical scrapie

Ovine BSE

  

(n = 4)

(n = 2)

(n = 3)

(n = 5)

1

Dorsal nucleus of the vagus

0.00 (± 0.00)

0.00 (± 0.00)

2.33 (± 0.58)

3.20 (± 0.84)

2

Hypoglossal nucleus

0.00 (± 0.00)

0.00 (± 0.00)

0.00 (± 0.00)

0.60 (± 0.55)

3

Reticular formation

0.00 (± 0.00)

0.00 (± 0.00)

2.66 (± 0.58)

3.00 (± 0.71)

4

Midline raphe (caudal)

0.00 (± 0.00)

0.00 (± 0.00)

0.66 (± 0.58)

1.00 (± 0.82)

5

Accessory cuneate nucleus

0.00 (± 0.00)

0.00 (± 0.00)

0.00 (± 0.00)

1.00 (± 0.71)

6

Olivary nuclei

0.00 (± 0.00)

0.00 (± 0.00)

0.33 (± 0.58)

0.00 (± 0.00)

7

Vestibular complex

0.00 (± 0.00)

0.00 (± 0.00)

0.00 (± 0.00)

0.00 (± 0.00)

8

Cochlear nucleus

0.00 (± 0.00)

0.00 (± 0.00)

0.00 (± 0.00)

0.00 (± 0.00)

9

Nucleus of the spinal tract of the trigeminal nerve

0.00 (± 0.00)

0.00 (± 0.00)

1.00 (± 1.00)

1.80 (± 0.84)

10

Midline raphe (rostral)

0.00 (± 0.00)

0.00 (± 0.00)

2.33 (± 0.58)

0.67 (± 0.58)

11

Cerebellar vermis - nodulus

1.00 (± 0.82)

2.00 (± 1.41)

0.00 (± 0.00)

0.25 (± 0.50)

12

Cerebellar vermis -excluding nodulus

1.75 (± 1.26)

3.00 (± 0.00)

0.00 (± 0.00)

0.00 (± 0.00)

13

Central grey matter

0.00 (± 0.00)

0.00 (± 0.00)

2.33 (± 0.58)

1.60 (± 0.55)

14

Red nucleus

0.00 (± 0.00)

0.00 (± 0.00)

0.33 (± 0.58)

0.00 (± 0.00)

15

Substantia nigra

0.50 (± 0.58)

0.00 (± 0.00)

3.66 (± 0.58)

1.80 (± 1.30)

16

Lateral geniculate nucleus

0.00 (± 0.00)

0.00 (± 0.00)

0.66 (± 0.58)

0.20 (± 0.45)

17

Dorsomedial thalamic nuclei

0.05 (± 0.58)

0.50 (± 0.71)

3.00 (± 0.00)

1.40 (± 1.14)

18

Ventrolateral thalamic nuclei

1.00 (± 0.00)

0.00 (± 0.00)

1.66 (± 0.58)

0.00 (± 0.00)

19

Hypothalamus

0.00 (± 0.00)

0.00 (± 0.00)

3.33 (± 0.58)

1.80 (± 0.84)

20

Head of the caudate nucleus

2.50 (± 1.00)

3.00 (± 0.00)

0.66 (± 1.15)

1.20 (± 0.84)

21

Nucleus accumbens

1.00 (± 0.82)

2.00 (± 1.41)

2.00 (± 2.00)

0.40 (± 0.55)

22

Frontal cortex

2.25 (± 0.96)

3.00 (± 1.41)

0.00 (± 0.00)

0.00 (± 0.00)

  1. See also Figure 1.