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Table 1 Individual case data of genotype, breed, inoculum, route of inoculation, incubation periods and clinical signs

From: The natural atypical scrapie phenotype is preserved on experimental transmission and sub-passage in PRNP homologous sheep

Case no

Breed/genotype

Challenged with

Route

Age at challenge (months)

Ip (days)

Clinical signs

1*

Cheviot AHQ/AHQ

AHQ -atypical passive (PG1347/04) Portland

Intracerebral

5.5

378

Behavioural changes (confusion, separation from others), compulsive behaviour (spontaneous nibbling, circling clockwise), mild hind limb ataxia, weight loss, normal menace response, no signs of pruritus

2

Cheviot AHQ/AHQ

As above

Intracerebral

5.5

1057

Compulsive behaviour (circling anti-clockwise), absent menace response in the left eye, head tremor, general ataxia, no weight loss, no signs of pruritus

3

Cheviot AHQ/AHQ

Active surveillance - breed not known

Intracerebral

5.5

878

Behavioural change (nervousness), bilateral absent menace response, head tremor, general ataxia, minor weight loss

4

Cheviot AHQ/AHQ

Same case as above

Intracerebral

6

990

Behavioural changes (confusion, separation from others), bilateral absent menace response, head tremor, general ataxia, no weight loss, no signs of pruritus

5

Cheviot AHQ/AHQ

Subpassage of material from case 1

Intracerebral

3

667

No behavioural changes, bilateral absent menace response, general ataxia, no weight loss, no signs of pruritus

6

Cheviot AHQ/AHQ

Subpassage of material from case 1

Intracerebral

3

747

Compulsive behaviour (circling anti-clockwise), bilateral absent menace response, head tremor, general ataxia & hypermetria, minor weight loss, no signs of pruritus

7

Cheviot AHQ/AHQ

Subpassage of material from case 1

Intracerebral

3

671

Behavioural changes (confusion), bilateral absent menace response, head tremor, general ataxia, minor weight loss, no signs of pruritus

8

Cheviot AHQ/AHQ

(PG519/06) AHQ/AHQ passive case - Cheviot

Intracerebral

3

607

Behaviour changes (dullness, teeth grinding), normal menace response, head tremor, general ataxia, weight loss, no signs of pruritus

9

Cheviot AHQ/AHQ

(PG519/06) AHQ/AHQ passive case - Cheviot

Intracerebral

3

833

Behavioural changes (confusion, separation from others), compulsive behaviour (circling anti-clockwise), normal menace response, general ataxia, minor weight loss, no signs of pruritus

10

Cheviot AHQ/AHQ

Bovine BSE

oral

4

573

Abnormal behaviour (confusion), signs of pruritus (frequent rubbing, positive scratch test, wool loss), mild ataxia

11

Cheviot AHQ/AHQ

Bovine BSE

oral

4.5

595

Head tremor, signs of pruritus (frequent rubbing, wool loss, positive scratch test), minor weight loss

12

Cheviot AHQ/AHQ

Bovine BSE

oral

4.5

617

Signs of pruritus (wool loss), weight loss

13

Cheviot AHQ/AHQ

Bovine BSE

oral

8

642

Abnormal behaviour (separation from others), normal menace response, head tremor, signs or pruritus (frequent rubbing), mild ataxia, weight loss

14

Cheviot AHQ/AHQ

Bovine BSE

oral

4.5

664

Abnormal behaviour (teeth grinding), signs of pruritus (frequent rubbing, wool loss), weight loss

15

British milksheep X Finn Dorset AHQ/AHQ

Classical scrapie

Natural

Not applicable

9 years at clinical onset

Abnormal behaviour (teeth grinding), ataxia, no signs of pruritus

16

British milksheep X Finn Dorset AHQ/AHQ

Classical scrapie

Natural

Not applicable

5 years at clinical onset

No behavioural abnormalities, mild ataxia, pruritus (positive scratch test)

17

British milksheep X Finn Dorset AHQ/AHQ

Classical scrapie

Natural

Not applicable

3 years 9 months at clinical onset

No behavioural abnormalities, mild ataxia, signs of pruritus (frequent rubbing)

18

Cheviot ARQ/VRQ

Classical scrapie

Intracerebral

10

537

Abnormal behaviour (nervousness, separation from others), normal menace response, head & body tremor, signs of pruritus (positive scratch test, rubbing with nibble reflex), ataxia, weight loss

19

Dorset ARQ/VRQ

Classical scrapie

Intracerebral

10

605

Abnormal behaviour (nervousness), normal menace response, head tremor, signs of pruritus (rubbing with nibble reflex), mild ataxia, weight loss

20

Dorset VRQ/VRQ

Classical scrapie

Intracerebral

11

126

Abnormal behaviour (dullness), absent menace response in the eye, signs of pruritus (positive scratch test, frequent rubbing), hind limb ataxia, minor weight loss

  1. Ip = incubation period.
  2. * This case previously reported [13].