Monitoring of clinical signs in goats with transmissible spongiform encephalopathies

BMC Veterinary Research

Table 3 Signs of scrapie-negative goats kept for milk collection or monitoring of clinical progression

Animal	Days at VLA	Genotype _{127-142-211-222-240}	Breed	Clinical status & signs at arrival	Clinical status & signs prior to cull
G08-1136	38	GIRQP/GMRQP	AN	No TSE signs (difficult to milk)*	No TSE signs^1,4
G08-1376	38	GIRQP/GIRQP	AN	No TSE signs (difficult to milk)*	No TSE signs^1,4
G08-1382	39	GIRQP/GMRQP	AN	No TSE signs (difficult to milk)*	No TSE signs^1,4
G08-1122	65	GIRQP/GMRQP	AN	No TSE signs (difficult to milk)*	No TSE signs^2-4
G08-1342	25	GIRQP/GIRQP	AN	No TSE signs (difficult to milk)*	Inconclusive (kicking and lying down at milking)^2-4
G08-1454	37	GIRQP/GMRQP	SA	No TSE signs (difficult to milk)*	Inconclusive (leg tremor)^1,4
G08-1115	65	GMRQP/GMRQP	AN	Inconclusive (head and body tremor, teeth grinding)	Inconclusive [body tremor, inconclusive scratch test (crouching), also diarrhoea]^2-4
G08-1144	39	GMRQP/GMRQP	SA	Scrapie (positive scratch test, repeated startle to auditory stimuli)	Inconclusive (pruritic behaviour on camera recordings but negative scratch test)^1,3

AN = Anglo-Nubian, SA = Saanen.
The clinical TSE status on arrival was assessed using the short protocol; for the assessment of the clinical TSE status prior to cull clinical assessments (short¹ or long² protocol), CCTV observations³ and behaviour at milking⁴ were taken into consideration.
* Inconclusive signs if behaviour during milking was included.

ISSN: 1746-6148