Table 2 Disease specific PrP (PrPd) detection in gastrointestinal tract and associated lymphoid and nervous tissues in pre-clinical stages of disease
From: Accumulation and dissemination of prion protein in experimental sheep scrapie in the natural host
Tissue | Time post infection (days) Number positive/number examined | |||||
|---|---|---|---|---|---|---|
(21) | (28) | (55) | (81) | (110) | (147) | |
Distal ileum Peyer's patch | 1/3 | 5/6 | 8/8 | 10/10 | 10/10 | 3/3 |
Jejunum Peyer's patch | 0/3 | 1/4 | 6/8 | 8/10 | 9/9 | 3/3 |
Mesenteric lymph node | 0/3 | 0/6 | 1/8 | 7/10 | 10/10 | 3/3 |
Palatine tonsil | 0/3 | 1/6 | 4/7 | 9/10 | 9/10 | 3/3 |
Pharyngeal tonsil | 0/3 | 0/6 | 3/8 | 8/10 | 10/10 | 2/3 |
Medial retropharyngeal lymph node | 0/3 | 1/6 | 5/8 | 10/10 | 10/10 | 3/3 |
Lateral retropharyngeal lymph node | 0/3 | Nd | 0/5 | 3/10 | 7/9 | 3/3 |
Enteric nervous system | 0/3 | 0/6 | 0/8 | 0/10 | 10/10 | 2/3 |