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Figure 8 | BMC Veterinary Research

Figure 8

From: Gene expression profiling in equine polysaccharide storage myopathy revealed inflammation, glycogenesis inhibition, hypoxia and mitochondrial dysfunctions

Figure 8

Relationships between inflammatory process, inhibition of glycogen synthase and hypoxia according to data mining Results of figure 5. The up-regulation of the glycogen synthase kinase (GSK3β) under its active form was responsible for the glycogen synthase (GYS1) inhibition. The up-regulation of GSK3β has another effect on hypoxia and low capillarization of the PSSM muscle. Phosphorylation of GSK3β increases the HIF1α destabilization which is degraded in the proteasome. Consequently, the low expression of HIF1α down-regulates VEGFα expression which contributes to a poor capillarization and increases chronic hypoxia of the regenerated muscle fibers. The PubMed ID of the related publications found by the data mining analysis were indicated on the figure (16464907; 15574430; 15227652; 15642371; 12764143; 11890723; 11029398).

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BMC Veterinary Research

ISSN: 1746-6148

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