Figure 6

Mitochondrial dysfunctions. Mitochondria is one of the compartment detected by electronic microscopy and data mining as illustrated in figure 4. In the mitochondria, the tRNA were severely down regulated (fold change between -4.83 and -2.27). The other mitochondrial genes ND2, ND3, ND5, ND6, COX2 and COX3 were moderately down-regulated but with low expression values (fold changes between -1.31 and -1.85). Other nuclear genes involved in the aerobic metabolism of the mitochondria were down regulated as well: UCP2, GNAS, SLC25a15, SLC2a2 (GLUT2), ATP5L, ATP5J, ATP5D and ATP5H. The PubMed ID of the related publications found by the data mining analysis were indicated on the figure (8611159; 7533543; 2988521).