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Figure 1 | BMC Veterinary Research

Figure 1

From: Gene expression profiling in equine polysaccharide storage myopathy revealed inflammation, glycogenesis inhibition, hypoxia and mitochondrial dysfunctions

Figure 1

Histological evaluation of muscular biopsies from Norman Cob horses. (A) Severe form of polysaccharide storage myopathy corresponding to a homozygous horse (# 44) for the GYS1 c.926 A allele. Numerous muscle fibers contained abnormal accumulation of polysaccharidic material (arrowheads). The endomysium was focally infiltrated by mononuclear cells (°), some adipocytes (*) and was diffusely thickened by fibrosis (arrows). (B) Mild form of polysaccharide storage myopathy corresponding to a heterozygous horse (# 54) for the GYS1 c.926 A allele. Compared to the severe form of the disease, the number of polysaccharide containing fibers (arrowheads) was lower and the endomysium was subnormal except for some fatty infiltration (°). (C) Muscle aspect of a control horse (#56). (A-C) Hematoxylin-eosin-safranine staining.

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BMC Veterinary Research

ISSN: 1746-6148

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