Disruption of chromosome 11 in canine fibrosarcomas highlights an unusual variability of CDKN2Bin dogs

Aguirre-Hernández, Jesús; Milne, Bruce S; Queen, Chris; O'Brien, Patricia CM; Hoather, Tess; Haugland, Sean; Ferguson-Smith, Malcolm A; Dobson, Jane M; Sargan, David R

doi:10.1186/1746-6148-5-27

BMC Veterinary Research

Table 2 CFA11 loss of heterozygosity.

From: Disruption of chromosome 11 in canine fibrosarcomas highlights an unusual variability of CDKN2Bin dogs

Feature*	Sequence type	Mb Distance From Top	LE blood genotype§	LE tumour genotype	Observations
CAMC11.009	Microsatellite	4.985028	387, 387	387, 387
AHT137	Microsatellite	5.829562	148, 148	148, 148
REN161P13	Microsatellite	7.106779	189, 189	189, 189
CAMC11.008	Microsatellite	8.593416	195, 195	195, 195
FH3203	Microsatellite	8.623136	89, 89	89, 89
CAMC11.010	Microsatellite	11.425726	307, 307	307, 307
FH4031	Microsatellite	14.237434	312, 331	312, 331	LOH
REN286P10	Microsatellite	17.844923	182, 185	182, 185
REN242K04	Microsatellite	19.23201	328, 328	328, 328
CAMC11.022	Microsatellite	20.94395	164, 169	164, 169
CAMC11.021	Microsatellite	24.758282	242, 250	242, 250
REN142O09	Microsatellite	26.338024	256, 261	256, 261
CAMC11.020	Microsatellite	29.356331	332, 332	332, 332
CAMC11.001	Microsatellite	31.434645	264, 264	264, 264
FH2004	Microsatellite	32.161602	240, 240	240, 240
CAMC11.003	Microsatellite	33.777804	285, 285	285, 285
FH2710	Microsatellite	34.47053	187, 187	187, 187
CAMC11.004	Microsatellite	34.561666	247, 363	249, 249
FH2874	Microsatellite	35.143202	177, 177	177, 177
CAMC11.005	Microsatellite	35.801351	327, 327	327, 327
CAMC11.006	Microsatellite	36.813802	321, 325	321, 325
FH2319	Microsatellite	37.54361	304, 334	304, 334
FH2982	Microsatellite	41.069406	361, 379	361, 379
CAMC11.019	Microsatellite	41.843895	243, 243	243, 243
FH2706	Microsatellite	43.991845	201, 201	201, 201
CAMC11.026	Microsatellite	44.172674	224, 226	224, 226	LOH
CDKN2A	Gene, exon 2	44.255474	Present	Missing
Contig_16328	contig end	44.258553
Gap in dog sequence		44.258554
CDKN2A	Gene, exon 1α	Undetermined
Gap in dog sequence		44.260435
Contig_16329	contig start	44.260436
CDKN2A	Gene, exon 1β	44.280332	Present	Present
CAMC11.027	Microsatellite	44.288351	306, 306	306, 306
CDKN2B	Gene, exon 2	44.291018	Present	Missing
CDKN2B	Gene, exon 1	44.293951	Heterozygous	Missing
CAMC11.029	Microsatellite	44.304276	256, 262	256, 256	LOH
CAMC11.017	Microsatellite	45.277711	207, 238	207, 238
C11.868	Microsatellite	48.547399	216, 216	216, 216
CAMC11.016	Microsatellite	50.214468	223, 223	223, 223
CAMC11.015	Microsatellite	52.827522	209, 213	209, 213
CAMC11.014	Microsatellite	55.676158	268, 268	268, 268
FH2019	Microsatellite	56.07231	211, 211	211, 211
FH3238	Microsatellite	57.734062	276, 276	276, 276
REN249L05	Microsatellite	58.631801	175, 175	175, 175
TGFBR1	Gene	59.220624
CAMC11.024	Microsatellite in TGFRB1 intron 7	59.239311	310, 310	310, 310
CAMC11.013	Microsatellite	59.911747	338, 346	338, 346
CAMC11.023	Microsatellite	61.260282	265, 277	265, 277
REN147O02	Microsatellite	61.367981	243, 243	243, 243
CAMC11.012	Microsatellite	63.816291	218, 222	218, 222
CAMC11.011	Microsatellite	67.610944	212, 212	212, 212
C11.873	Microsatellite	67.767854	136, 144	136, 144
FH3065	Microsatellite	72.608147	185, 185	185, 185
DGN13	Microsatellite	72.807881	303, 326	303, 326

*Microsatellites are listed according to their position in Ensembl's CanFam 2.0 (July 2008). The position of exons within the CDKN2B-CDKN2A gene cluster is provided, along with the position of the gap between contigs 16328 and 16329, and the location of TGFBR1. ^§The numbers in the genotype columns correspond to the PCR product sizes (in base pairs) of the alleles, as determined by the sequencing instrument.

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ISSN: 1746-6148

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