Effect of tepoxalin and its metabolite on proteoglycan degradation expressed as an average value from four dogs after 7 days of culture. Explants were cultured in serum free media containing IL-1β (100 ng/ml) and OSM (50 ng/ml) along with tepoxalin (T) or its metabolite (M) at ×10-5, ×10-6 or ×10-7 M concentrations. Proteoglycan release (GAG in medium) is expressed as milligrams of GAG per gram of wet weight of cartilage. Data represents means + standard error, n = 7. P values correspond to comparisons to the positive control.