Skip to main content

Table 1 Immunohistochemical distribution of PrPSc in neural and extraneural tissues of two FSE cats and control cats

From: Immunohistochemical study of PrPScdistribution in neural and extraneural tissues of two cats with feline spongiform encephalopathy

Organ system

FSE cat no. 1

FSE cat no. 2

Contol cats (n = 6)

Antibodies

34c9

6H4

34c9

6H4

34c9

6H4

Brain:

      

Cerebrum:

      

Cerebral cortex

+++

+++

+++

+++

-

-

Gyrus dentatus

+++

+++

+++

+++

-

-

Cerebellum:

      

Molecular layer

+

+

+

+

-

-

Purkinje cell layer

-

-

-

-

-

-

Granular cell layer

+++

+++

+++

+++

-

-

Brain stem

+++

+++

+++

+++

-

-

Nervus opticus

++

++

++

++

-

-

Retina:

      

Rod and cone layer

+

+

+

+

-

-

Outer nuclear layer

-

-

-

-

-

-

Outer plexiform layer

+

+

+

+

-

-

Inner nuclear layer

-

-

-

-

-

-

Inner plexiform layer

+++

+++

+++

+++

-

-

Ganglion cell layer

+

+

+

+

-

-

Pituitary gland:

      

Pars distalis

-

-

-

-

-

-

Pars intermedia

-

-

-

-

-

-

Neurohypophysis

+++

+++

+++

+++

-

-

Trigeminal ganglion

n.d.

n.d.

+++

+++

-

-

Myenteric plexus (duodenum, jejunum, colon)

+

+

+

+

-

-

Lymphoid system:

      

Spleen

-

-

-

-

-

-

GALT

n.d.

n.d.

-

-

-

-

Bone marrow

-

-

-

-

-

-

Nictitating membrane follicles

n.d.

n.d.

-

-

-

-

Heart

-

-

-

-

-

-

Lung

-

-

-

-

-

-

Thyroid gland

-

-

-

-

-

-

Parathyroid gland

-

-

-

-

-

-

Salivary gland

n.d.

n.d.

-

-

-

-

Nasal mucosa

n.d.

n.d.

-

-

-

-

Liver

-

-

-

-

-

-

Pancreas

-

-

-

-

-

-

Kidney:

      

Glomerular capillary tuft

+°

-

-

-

++3/6°

+ 2/6°

Tubules

-

-

-

-

-

-

Adrenal gland:

      

Zona glomerulosa

-

-

n.d.

n.d.

-

-

Zona fasciculate

-

-

n.d.

n.d.

-

-

Zona reticularis

-

-

n.d.

n.d.

-

-

Medulla

+

+

n.d.

n.d.

-

-

Muscle (striated)

n.d.

n.d.

-

-

-

-

  1. + = weak; ++ = moderate; +++ = strong immunostaining; n.d. = not done; ° = considered as unspecific