Figure 5
Alignment of amino acid sequences in the proteolytic cleavage site of the precursor F 0 protein (modified from Kibenge et al. [19]). The amino acid sequence corresponding to the fusion protein of the Chilean ISAV in this disease outbreak is highlighted in yellow. The designation of amino acid inserts IN1, IN2, and IN3 are as reported by Devold et al. [21]. The unique 11-amino acid insert found in the Chilean ISAV in this disease outbreak is designated IN4. Other sources of information are indicated as *Devold et al. [21], **Markussen et al. [20], and ***Plarre and Nylund (2004; SF83/04, GenBank Accession No. AY744392). It has been suggested by Markussen et al. [20] that ISAV isolate SF83/04 represents a mixed virus infection of HPR0 and another HPR group, which might explain the confusion in the virulence designation.