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Table 4 Clinical findings in non-pruritic BSE cases of the oral BSE pathogenesis study

From: Pruritus is a common feature in sheep infected with the BSE agent

Animal SM1391 SM1430 SM1394 SP3652 SM1435 SM1404
Breed and genotype Romney ARQ/ARQ Romney ARQ/ARQ Romney ARQ/ARQ Suffolk ARQ/ARQ Romney ARQ/ARQ Romney ARQ/ARQ
MPI 16 16 22 16 22 22
Postmortem test result HP neg. IHC pos. HP neg. IHC pos. HP neg. IHC pos. HP neg. IHC pos. HP pos. IHC pos. HP pos. IHC pos.
Behaviour change No No No No N/A No
Pruritic behaviour 1 No No Rubbing once No Rubbing once No
Fleece change No No No No No No
Skin Lesion No No No No No No
Bruxism when observed or examined No No No No No No
Tremors No No No No N/A No
Ataxia No No No No No No
Weight loss No <5% No No <5% <5%
  1. 1 The display of a positive scratch test, a self-induced scratch response, self-nibbling, rubbing or scratching
  2. HP = Histopathological examination of the brain
  3. IHC = Immunohistochemical examination of the brain
  4. neg./pos. = negative/positive
  5. N/A = not assessed
  6. Romney sheep were inoculated at approximately six months of age, Suffolk sheep at approximately four months of age.