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Table 4 Mixed-inheritance model parametersa for dichotomous deafness in Jack Russell Terriers

From: Heritability and complex segregation analysis of deafness in Jack Russell Terriers

 

Polygenic Variance

Major Locus Variance

Additive Effect (a)

Dominance Deviation (d)

Ï„AAb

Ï„AB

Ï„BB

Frequency (q)

General Major Locus, Mendelian Transmission

Mean

1.48

8.46

3.64

-2.65

1.0

0.5

0.0

0.84

Median

1.53

9.72

3.89

-2.57

-

-

-

0.83

SD

0.84

10.21

1.18

1.35

-

-

-

0.11

Eff Sample Sizec

1417.3

1007.3

980.2

1013.6

-

-

-

1198.6

Conv Score (p)d

1.32 (0.19)

1.55 (0.12)

1.68 (0.09)

1.71 (0.09)

-

-

-

1.49 (0.14)

HDRe 95% Low

0.00

0.00

1.48

-5.21

-

-

-

0.38

HDR 95% High

3.22

33.14

7.77

0.06

-

-

-

1.00

Recessive Major Model, Mendelian Transmission

Mean

2.21

13.19

3.68

-3.68

1.0

0.5

0.0

0.74

Median

2.33

12.32

3.65

-3.65

-

-

-

0.75

SD

0.60

6.03

0.84

0.84

-

-

-

0.41

Eff Sample Size

1330.9

1121.0

1032.6

1032.6

-

-

-

1064.1

Conv Score (p)

-1.27 (0.20)

1.51 (0.13)

1.74 (0.08)

1.74 (0.08)

-

-

-

1.42 (0.16)

HDR 95% Low

0.39

0.00

2.15

-6.23

-

-

-

0.44

HDR 95% High

3.16

45.89

7.42

-1.03

-

-

-

1.00

General Major Locus, Non-Mendelian Transmission

Mean

1.46

6.53

4.13

-3.01

0.63

0.52

0.18

0.94

Median

1.57

6.34

4.36

-3.29

0.70

0.51

0.01

0.99

SD

0.88

8.18

1.62

1.57

0.05

0.05

0.13

0.03

Eff Sample Size

1387.6

1109.2

1290.3

1088.1

1172

1043

941

1186.4

Conv Score (p)

1.18 (0.24)

1.40 (0.16)

1.37 (0.17)

1.19 (0.23)

1.08 (.28)

1.19 (.23)

1.75 (.08)

0.97 (0.33)

HDR 95% Low

0.00

0.00

0.53

-7.11

0.52

0.26

0.00

0.75

HDR 95% High

3.23

33.69

8.04

-0.48

0.86

0.66

0.63

1.00

  1. a Estimates are taken from a Gibbs sample of 9,000 values.
  2. b Mendelian transmission parameter; the probability of transmitting an "A" allele. For Mendelian transmission these values are fixed as 1.0, .50 and 0.0 for putative major genotypes AA, AB and BB, respectively. Non-Mendelian transmission implies estimation of these values from the data.
  3. c Effective sample size.
  4. d Gibbs sample convergence statistic; Geweke (1992).
  5. e Highest density region