Relevance of the regional lymph node in scrapie pathogenesis after peripheral infection of hamsters

BMC Veterinary Research

Table 2 Survival times of hamsters that underwent regional lymphadenectomy before scrapie infection

	Sham operation 4 weeks before infection		Ectomy 4 weeks before infection
	individual survival	mean ± SD	individual survival	mean ± SD
Infectious dose: 20 μl 2% 263K-homogenate	105; 105; 108; 115; 115; 122	112 ± 7	108; 112; 112; 115; 115; 115	114 ± 4
Infectious dose: 20 μl 0.1% 263K-homogenate	131; 138; 168; 176 176; 182; 182; 200	169 ± 23	125; 127; 127; 131; 134; 168; 182; 218	155 ± 34
Infectious dose: 20 μl 0.001% 263K-homogenate	219; 247; 247; 288; 300; 308; 314*	268 ± 36 (without *)	308; 314; 314; 314; 314; 314; 314

Individual survival times (days) and mean survival times (days ± SD) of hamsters that underwent regional lymphadenectomy of the Ln. popliteus, or sham-operation, four weeks before footpad infection with a high, a low or a very low dose of 263K-scrapie agent. Asterisk indicates animals that did not show onset of scrapie symptoms until the termination of the experiment at 314 dpi.

ISSN: 1746-6148