Figure 3
From: Relevance of the regional lymph node in scrapie pathogenesis after peripheral infection of hamsters
PET blot analysis of PrPTSE deposition in coronal brain slices of hamsters that were sham-operated or lymphadenectomized four weeks before footpad infection with the 0.001% inoculum. Levels correspond to regions I-III as indicated in figure 1 (A-C, E-G, I-K), and to a region containing the red nucleus (from where neural projections extend to the sciatic nerve innervating the footpad [D, H, L]). A-D: Samples from a sham-operated hamster that developed terminal scrapie at 300 dpi. E-H: Samples from the sham-operated hamster that remained free of scrapie symptoms until 314 dpi. I-L: Samples from one animal representative for five lymphadenectomized hamsters that remained free of scrapie symptoms until 314 dpi.