Histopathology of the terminal ileum from paucibacillary sheep. (a) Ziehl-Neelsen stain (× 250) showing the absence of mycobacteria. (b) H&E stained low power (×250) showing mixed inflammatory infiltrate into lamina propria comprising lymphocytes, eosinophils, macrophages and multinucleate giant cells. (c) H&E stained high power (×400) showing multinucleate giant cells (large arrow) adjacent to a crypt. There is an associated proprial inflammatory reaction dominated by lymphocytes and eosinophils (small arrows).