Electron micrograph of NR sheep liver (Cu 800 μg/g). Hepatocytes (mid zone) show mitochondrial distention and frequent gross swelling with rupture (M); peroxizomes (P) and hypertrophied smooth endoplasmic reticulum (SER). Bile canaliculus (bc). Hepatic stellate cell (HSC) with collagen fibrils (C) penetrating intercellular space and separating adjacent hepatocytes. Bar = 2 μm.