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Table 1 Immunolabelling pattern by brain area

From: Different prion disease phenotypes result from inoculation of cattle with two temporally separated sources of sheep scrapie from Great Britain

Case No

Group

Clinical

presentation

Obex

Rostral

medulla/

Cerebellum

Rostral

midbrain

Rostral

thalamus

Basal

ganglia/

frontal

cortex

Antibody

119/01

Pre 1975

Dull form

1

1 (Cerebellum negative)

1

1

1

486

609/01

Pre 1975

Dull form

1

1

1

1

1

486

743/01

Pre 1975

Dull form

1

1

1

1

1

145

749/01

Pre 1975

Dull form

1

Negative

1

1

1

145

959/01

Pre 1975

Dull form

1

1

1

1

1

145

1189/01

Pre 1975

Dull form

1

1

1

1

1

145

045/02

Pre 1975

Dull form

1

1

1

1

1

145

754/02

Pre 1975

Dull form

1

1

1

1

1

145

166/04

Pre 1975

Dull form

1

1

1

1

1

145

116/01

Post 1990

Dull form

2

2

3

3

3

486

920/01

Post 1990

Nervous form

2

2

3

3

3

145

1063/01

Post 1990

Dull form

2

2

3

3

3

145

152/02

Post 1990

Dull form

1

1

1

1+3

1+3

145

512/02

Post 1990

Nervous form

1

1

1

1

1+3 (Cortex negative)

145

1215/02

Post 1990

Dull form

2

2

3

3

3

145

96/04

Post 1990

Dull form

2

2

3

3

3

145

  1. Group 1 – Predominantly neuronal with less neuropil labelling
  2. Group 2 – Predominantly neuropil with less neuronal labelling (in both groups the overall distribution of IHC types is similar)
  3. Group 3 – Like group 2 but with prominent aggregated/stellate forms