| |
age, sex
|
onset of symptoms
|
clinical
|
family affected
|
legs
|
patella
|
heart
|
PA
|
aorta
|
eyes
|
other tissues
|
ultrasound
|
|---|
|
1
|
1 y, M
|
6 mos
|
four
|
sire
|
4 mod
|
ND
|
cor +
|
ND
|
+
|
both+
|
nuchal+
|
2/2 front SLs
|
|
2
|
1 y, F
|
6 mos
|
four
|
sire
|
4 mild
|
ND
|
cor +
|
ND
|
+
|
-
|
nuchal, lung +
|
2/2 front SLs
|
|
3
|
18 mo M
|
6 mos
|
four
|
parents
|
4 mild
|
ND
|
ND
|
ND
|
ND
|
ND
|
nuchal+
|
ND
|
|
4
|
18 mo M
|
6 mos
|
four
|
parents
|
4 mod
|
ND
|
ND
|
ND
|
ND
|
ND
|
nuchal+
|
ND
|
|
5
|
1.5 y, M
|
at 1 y
|
four
|
dam
|
4 mild
|
+
|
-
|
+
|
-
|
both+
|
lung +
|
4 SLs
|
|
6
|
2 y, F
|
birth
|
four
|
sire
|
4 mod
|
ND
|
ND
|
ND
|
+
|
ND
|
ND
|
¾ SLs
|
|
7
|
3 y, F
|
6 mos
|
rear
|
parents
|
4 mild
|
+
|
cor +
|
ND
|
+
|
both +
|
nuchal, lung +
|
4 SLs
|
|
8
|
3 y, M
|
1 year
|
front legs
|
no
|
4 severe
|
ND
|
cor +
|
ND
|
+
|
ND
|
nuchal+
|
ND
|
|
9
|
7 y, F
|
years
|
four
|
dam
|
4 severe
|
ND
|
valve+
|
+
|
+
|
ND
|
lung +
|
2/4 SLs
|
|
10
|
8 y, M
|
years
|
four
|
sire, foals
|
1 SL exam, mod*
|
ND
|
ND
|
ND
|
ND
|
L eye +
|
nuchal+
|
4 SLs
|
|
11
|
9 y, F
|
at 9 y
|
rear
|
dam
|
4 severe
|
ND
|
valve+
|
+
|
+
|
ND
|
lung +
|
4 SLs
|
|
12
|
9 y, M
|
at 6 y
|
four
|
no
|
4 mild
|
+
|
cor +
|
+
|
+
|
both+
|
-
|
4 SLs
|
|
13
|
9 y, M
|
years
|
fallen crest, legs
|
dam
|
4 mild
|
ND
|
cor +
|
ND
|
-
|
both +
|
nuchal, lung +
|
ND
|
|
14
|
11 y, F
|
years
|
four
|
no
|
1 SL exam, mild*
|
ND
|
ND
|
ND
|
ND
|
R eye +
|
nuchal+
|
2/2 hind SLs
|
|
15
|
15 y, F
|
years
|
four
|
no
|
4 mod
|
ND
|
ND
|
ND
|
+
|
ND
|
ND
|
4 SLs
|
|
16
|
15 y, F
|
years
|
front
|
foal
|
4 mod
|
+
|
cor +
|
PA+
|
+
|
both +
|
nuchal+
|
ND
|
|
17
|
15 y, F
|
years
|
four
|
sire, son
|
4 mod
|
ND
|
cor +
|
ND
|
+
|
both +
|
nuchal, shoulder+
|
ND
|
|
18
|
18 y, F
|
years
|
four
|
no
|
1 leg exam, severe*
|
ND
|
ND
|
ND
|
ND
|
ND
|
ND
|
4 SLs
|
|
19
|
18 y, F
|
years
|
rear legs
|
foals
|
4 mild
|
ND
|
ND
|
ND
|
-
|
R eye +
|
nuchal, lung +
|
4 SLs
|
|
20
|
21 y, M
|
late onset
|
four
|
no
|
4 mod
|
+
|
cor +
|
-
|
-
|
R eye +
|
-
|
4 SLs
|
|
21
|
21 y, M
|
years
|
legs
|
no
|
4 severe
|
ND
|
cor +
|
ND
|
+
|
R eye +
|
lung +
|
4 SLs
|
|
22
|
unknown
|
unknown
|
unknown
|
no
|
4 mild
|
ND
|
-
|
ND
|
-
|
ND
|
-
|
ND
|
- Age: age at necropsy; ND: not done; legs: SDFT, DDFT and SL; cor: coronary artery; PA: pulmonary artery; nuchal: nuchal ligament
- Mild, mod (moderate), severe: describes the average severity of pathology in examined leg tendons and ligaments; +: accumulation of proteoglycans in other tissues; -: no proteoglycan accumulation
- *only limited tissue was available for examination
