Ultrastructural features of normal and DSLD-affected aorta. A. Normal smooth muscle cell from media from a healthy aorta. B. A smooth muscle cell from the media of DSLD-affected aorta reveals the presence of numerous cytoplasmic vacuoles (*). C. normal smooth muscle cell has a well defined cell membrane (▶). D. The cell membrane of a diseased media is disrupted and missing in places (▶). E and F. Organization of collagen fibrils and elastic fibers is similar in normal (E) and DSLD aorta (F). SMC: smooth muscle cell, EL: elastic lamina, C: collagen fibrils.