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Table 1 Comparison between experimental groups of the different scores for microscopic grading of cartilage and synovial alterations, obtained from decalcified samples

From: Effects of glucosamine and risedronate alone or in combination in an experimental rabbit model of osteoarthritis

CONTROL CTRL CTRL+GS CTRL+RS CTRL+GS&RS
  Median (25, 75) Median (25, 75) Median (25, 75) Median (25, 75)
Microscopic grading of cartilage alterations
Severity of cartilage pathology 0 (0, 0.5) e,f,g 0 (0, 0) c,e,f,g 0 (0, 0.5) b,e,f,g 0 (0, 1) e,f,g
Severity of chondrocyte pathology 0 (0, 1) 0.5 (0, 1.25) 0 (0, 1) 0.5 (0, 1)
Severity of proteoglycan pathology 0 (0, 0) 0.5 (0, 1) 0 (0, 0) 0 (0, 0)
Tidemark integrity 1 (0.75, 2) 0.5 (0, 1) 1 (0, 1) 1 (1, 1)
Microscopic grading of synovial changes
Lining cells characteristics 0 (0, 0) e,f,h 0 (0, 0) e,f,h 0 (0, 0) e,f,h 0 (0, 0) e,f,h
Presence of hyperplasia 0 (0, 0) e,f,g,h 0 (0, 1) e,f,h 0 (0, 0) e,f,g,h 0 (0, 0) e,f,g,h
Cell infiltration characteristics 0 (0, 0) e,f,g 0 (0, 0) e,g 0 (0, 0) e,f 0 (0, 0) e,f
OSTEOARTHRITIS OA OA+GS OA+RS OA+GS&RS
  median (25, 75) median (25, 75) median (25, 75) median (25, 75)
Microscopic grading of cartilage alterations
Severity of cartilage pathology 1 (0.5, 1.5) a,b,c,d,h 1 (1, 2) a,b,c,d,h 1 (0.5, 1.5) a,b,c,d,h 0 (0, 0.625) e,f,g
Severity of chondrocyte pathology 1 (0.5, 1.75) 1 (1, 3) 1 (0.5, 1.5) 1 (0, 1.125)
Severity of proteoglycan pathology 1 (0, 2) 1 (0.5, 3) 1 (0, 2.75) 3 (0.75, 4)
Tidemark integrity 0 (0, 1.5) 0 (0, 0) 1 (1, 1) 1 (0.25, 1)
Microscopic grading of synovial changes
Lining cells characteristics 1 (1, 1) a,b,c,d,g,h 1 (0, 2) a,b,c,d,g,h 0 (0, 0.25) e,f 0 (0, 0.625) a,b,c,d,e,f
Presence of hyperplasia 1 (1, 1.75) a,b,c,d,f,g,h 1.5 (1, 2) a,b,c,d,e,g,h 0.5 (0, 1) a,c,d,e,f 1 (0, 1) a,b,c,d,e,f
Cell infiltration characteristics 1 (0.25, 1) a,b,c,d,h 0.75 (0, 1) a,b,c,d,g,h 0 (0, 0.25) a,f 0 (0, 0.25) e,f
  1. CTRL: healthy + placebo; OA: osteoarthritis + placebo; CTRL + GS: healthy + glucosamine; OA + GS: osteoarthritis + glucosamine; CTRL + RS: healthy + risedronate; OA + RS: osteoarthritis + risedronate; CTRL + GS&RS: healthy + combined treatment of glucosamine and risedronate; OA + GS&RS: osteoarthritis + combined treatment of glucosamine and risedronate. Statistical differences p < 0.05: a vs. CTRL, b vs. CTRL + GS, c vs. CTRL + RS, d vs. CTRL + GSRS, e vs. OA, f vs. OA + GS, g vs. OA + RS, h vs. OA + GSRS.
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