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Table 1 BCG vaccination studies comparing the use of both one single dose or repeated doses of the vaccine in cattle and wildlife

From: Oral re-vaccination of Eurasian wild boar with Mycobacterium bovis BCG yields a strong protective response against challenge with a field strain

  Dose Interval Route Reference Effect of boosting
Red deer ( Cervus elaphus ) 2 doses of 2.5×106 cfu BCG Pasteur 8 weeks Subcutaneous [5] Two doses of vaccine were superior to one dose producing protection against infection.
Red deer ( Cervus elaphus ) 2 doses of 2×106 cfu BCG Pasteur 6 weeks Subcutaneous [18] Single-dose vaccines protected against disease. Boosting was required to protect against infection.
White-tailed deer ( Odocoileus virginianus ) 2 doses of 107 cfu BCG Pasteur 6 weeks Subcutaneous [19] Pathology scores were lower in deer receiving 2 doses of M. bovis BCG compared to unvaccinated ones or those who received a single dose.
Brush-tailed possum ( Trichosurus vulpecula ) 12 doses of 1×108; 2 doses of 1×108 cfu BCG Pasteur 1 Week (12 doses); 6 weeks (2 doses) Intranasal aerosol and conjuntival instillation [20] The group vaccinated 12 times showed the greatest level of protection. Revaccination after a period of 6 weeks had no beneficial and no deleterious effects as compared to the protection induced by a single dose of vaccine.
Cattle 2 doses of 106 CFU BCG Pasteur 6 weeks Subcutaneous [21] Significantly less protection than those vaccinated only once. Revaccination reduced the level of protection induced by a single vaccination.