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Table 1 Comparison of plasma biomarker levels and lipoprotein profiles among control, hyperlipidemia dogs with/without treatment

From: Comparison of plasma lipoprotein profiles and malondialdehyde between hyperlipidemia dogs with/without treatment

Group (n)

Control (13)

Hyperlipidemia

Untreatment (4)

With treatment (4)

Age

8.0 (2.8-9.3)

9.5 (6.0-11.5)

12.5 (12.-15.0)

Body condition score

3.0 (3.0-4.0)

3.5 (2.3-4.8)

3.0 (3.0-4.0)

Body weight (kg)

5.6 (4.3-14.5)

7.7 (3.0-21.3)

8.9 (5.6-26.9)

Total choresterol (mg/dL)

240 (170–351)

241 (231–358)

367 (347–390)

Triglycerid (mg/dL)

48 (28–163)

252 (196–311)*

81 (61–88)

Total protein (g/dL)

6.8 (6.4-7.4)

7.5 (6.7-8.0)

7.3 (7.1-7.7)

Albmin (g/dL)

3.3 (3.0-3.4)

3.4 (3.0-3.8)

3.3 (3.0-3.6)

Albumin/globulin ratio

0.88 (0.79-0.97)

0.83 (0.80-0.89)

0.78 (0.76-0.88)

Total bilirubin (mg/dL)

0.1 (0.1-0.2)

0.2 (0.1-0.2)

0.1 (0.1-0.2)

AST (IU/L)

33 (24–39)

35 (20–38)

33 (26–45)

ALT (IU/L)

44 (37–67)

40 (24–65)**

123 (75–315)*

ALP (IU/L)

127 (72–218)

335 (101–2259)

877 (318–1113)*

γ-GTP (IU/L)

6.1 (3.9-7.7)

5.1 (2.8-7.7)

7.7 (6.0-35.8)

Total bile acid (mg/dL)

5.7 (2.5-23.5)

15.8 (6.4-104.3)

10.4 (6.2-31.2)

Glucose (mg/dL)

90 (81–110)

102 (96–109)

103 (90–375)

NEFA (mEq/L)

0.78 (0.64-0.97)

0.73 (0.55-1.14)

0.52 (0.41-0.65)

Insulin (ng/mL)

1.1 (0.8-1.7)

0.7 (0.6-1.1)

2.4 (1.2-2.5)

Adiponectin (μg/mL)

18.4 (15.9-30.1)

31.9 (17.1-38.9)

23.8 (19.0-25.9)

Cholesterol profiles

   

HDL2,3 (mg/dl)

191.8 (143.1-225.0)

191.2 (167.2-240.0)

229.7 (215.8-242.8)

HDL1 (mg/dl)

31.1 (24.3-85.5)

41.7 (25.2-124.4)

119.9 (96.3-136.6)

VLDL/LDL (mg/dl)

5.8 (3.3-14.4)

22.5 (16.5-35.7)*

21.5 (7.7-35.9)

CM (mg/dl)

0.0 (0.0-0.2)

1.5 (0.0-6.7)

0.0 (0.0-0.0)

Triglyceride profiles

   

HDL2,3 (mg/dl)

0.0 (0.0-0.0)

0.0 (0.0-0.0)

0.0 (0.0-0.2)

HDL1 (mg/dl)

0.5 (0.0-1.8)

0.9 (0.75-5.0)

3.0 (1.9-6.5)*

VLDL/LDL (mg/dl)

47.5 (28.1-108.4)

193.1 (119.0-264.5)*,**

67.9 (59.7-72.3)

CM (mg/dl)

0.5 (0.0-48.7)

58.6 (0.0-119.3)

5.6 (0.0-14.5)

  1. Values are presented as median. Numbers in parentheses present from 25% to 75% value.
  2. *Significantly different (p < 0.05) from the values of Control group by Kruskal-Wallis One Way Analysis of Variance on Ranks.
  3. **Significantly different (p < 0.05) from the values of hyperlipidemia with treatment group by Kruskal-Wallis One Way Analysis of Variance on Ranks.
  4. All dogs were also determined by palpation and inspection on with a body condition score (BCS: a 5 point scale) the five-point scale: (1) very thin, (2) underweight, (3) ideal, (4) overweight, and (5) obese.
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