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Table 1 Comparison of plasma biomarker levels and lipoprotein profiles among control, hyperlipidemia dogs with/without treatment

From: Comparison of plasma lipoprotein profiles and malondialdehyde between hyperlipidemia dogs with/without treatment

Group (n) Control (13) Hyperlipidemia
Untreatment (4) With treatment (4)
Age 8.0 (2.8-9.3) 9.5 (6.0-11.5) 12.5 (12.-15.0)
Body condition score 3.0 (3.0-4.0) 3.5 (2.3-4.8) 3.0 (3.0-4.0)
Body weight (kg) 5.6 (4.3-14.5) 7.7 (3.0-21.3) 8.9 (5.6-26.9)
Total choresterol (mg/dL) 240 (170–351) 241 (231–358) 367 (347–390)
Triglycerid (mg/dL) 48 (28–163) 252 (196–311)* 81 (61–88)
Total protein (g/dL) 6.8 (6.4-7.4) 7.5 (6.7-8.0) 7.3 (7.1-7.7)
Albmin (g/dL) 3.3 (3.0-3.4) 3.4 (3.0-3.8) 3.3 (3.0-3.6)
Albumin/globulin ratio 0.88 (0.79-0.97) 0.83 (0.80-0.89) 0.78 (0.76-0.88)
Total bilirubin (mg/dL) 0.1 (0.1-0.2) 0.2 (0.1-0.2) 0.1 (0.1-0.2)
AST (IU/L) 33 (24–39) 35 (20–38) 33 (26–45)
ALT (IU/L) 44 (37–67) 40 (24–65)** 123 (75–315)*
ALP (IU/L) 127 (72–218) 335 (101–2259) 877 (318–1113)*
γ-GTP (IU/L) 6.1 (3.9-7.7) 5.1 (2.8-7.7) 7.7 (6.0-35.8)
Total bile acid (mg/dL) 5.7 (2.5-23.5) 15.8 (6.4-104.3) 10.4 (6.2-31.2)
Glucose (mg/dL) 90 (81–110) 102 (96–109) 103 (90–375)
NEFA (mEq/L) 0.78 (0.64-0.97) 0.73 (0.55-1.14) 0.52 (0.41-0.65)
Insulin (ng/mL) 1.1 (0.8-1.7) 0.7 (0.6-1.1) 2.4 (1.2-2.5)
Adiponectin (μg/mL) 18.4 (15.9-30.1) 31.9 (17.1-38.9) 23.8 (19.0-25.9)
Cholesterol profiles    
HDL2,3 (mg/dl) 191.8 (143.1-225.0) 191.2 (167.2-240.0) 229.7 (215.8-242.8)
HDL1 (mg/dl) 31.1 (24.3-85.5) 41.7 (25.2-124.4) 119.9 (96.3-136.6)
VLDL/LDL (mg/dl) 5.8 (3.3-14.4) 22.5 (16.5-35.7)* 21.5 (7.7-35.9)
CM (mg/dl) 0.0 (0.0-0.2) 1.5 (0.0-6.7) 0.0 (0.0-0.0)
Triglyceride profiles    
HDL2,3 (mg/dl) 0.0 (0.0-0.0) 0.0 (0.0-0.0) 0.0 (0.0-0.2)
HDL1 (mg/dl) 0.5 (0.0-1.8) 0.9 (0.75-5.0) 3.0 (1.9-6.5)*
VLDL/LDL (mg/dl) 47.5 (28.1-108.4) 193.1 (119.0-264.5)*,** 67.9 (59.7-72.3)
CM (mg/dl) 0.5 (0.0-48.7) 58.6 (0.0-119.3) 5.6 (0.0-14.5)
  1. Values are presented as median. Numbers in parentheses present from 25% to 75% value.
  2. *Significantly different (p < 0.05) from the values of Control group by Kruskal-Wallis One Way Analysis of Variance on Ranks.
  3. **Significantly different (p < 0.05) from the values of hyperlipidemia with treatment group by Kruskal-Wallis One Way Analysis of Variance on Ranks.
  4. All dogs were also determined by palpation and inspection on with a body condition score (BCS: a 5 point scale) the five-point scale: (1) very thin, (2) underweight, (3) ideal, (4) overweight, and (5) obese.