Influence of the cardiac glycoside digoxin on cardiac troponin I, acid–base and electrolyte balance, and haematobiochemical profiles in healthy donkeys (Equus asinus)

Table 1 Mean values (± standard deviation) of acid–base and electrolyte parameters in donkeys ( n = 10) injected with digoxin

Time	pH	PCO₂(mmHg)	PO₂(mmHg)	BE (mmol/L)	HCO₃¯ (mmol/L)	SO₂(%)	Sodium (mmol/L)	Potassium (mmol/L)	Chloride (mmol/L)	AG (mmol/L)	Lactate (mmol/L)
T0	7.42 ± 0.02	42.0 ± 2.6	31.2 ± 1.9	2.6 ± 1.0	27.1 ± 0.9	60.5 ± 3.4	132 ± 3	4.5 ± 0.3	104 ± 2.9	9.3 ± 0.4	1.9 ± 0.5
T1	7.43 ± 0.03	41.7 ± 3.3	30.7 ± 2.0	3.2 ± 1.5	27.6 ± 1.2	56.0 ± 7.3	133 ± 4	4.6 ± 0.5	105 ± 3.8	10.3 ± 1.6	1.0 ± 0.2^b
T2	7.45 ± 0.04	39.4 ± 2.8^b	30.0 ± 0.8	2.9 ± 1.9	27.1 ± 1.4	60.5 ± 1.2	132 ± 5	4.4 ± 0.5	105 ± 3.4	8.6 ± 0.9	1.2 ± 0.4^b
T3	7.45 ± 0.01^b	38.3 ± 0.8^b	33.6 ± 2.1^b	2.9 ± 2.4	26.8 ± 1.7	68.5 ± 3.2^b	132 ± 3	4.8 ± 0.6	105 ± 3.7	8.8 ± 1.1	1.4 ± 0.6^b
T4	7.44 ± 0.02	37.0 ± 2.2^b	33.8 ± 1.2^b	2.0 ± 1.5	26.2 ± 1.4	65.7 ± 4.6^b	131 ± 3	4.2 ± 0.5	106 ± 3.5	9.5 ± 2.2	1.2 ± 0.3^b
T5	7.42 ± 0.01	39.7 ± 2.3^b	45.7 ± 16.6^b	2.4 ± 1.3	26.6 ± 1.4	74.4 ± 10.9^b	133 ± 4	5.0 ± 1.0	103 ± 2.8	8.7 ± 0.4	1.7 ± 0.6
T6	7.42 ± 0.03	40.6 ± 3.7	39.4 ± 11.4^b	2.0 ± 0.6	26.4 ± 1.0	70.9 ± 10.2^b	132 ± 3	4.9 ± 0.6	105 ± 3.4	9.1 ± 1.2	1.8 ± 0.4
T7	7.43 ± 0.02	41.8 ± 1.9	31.4 ± 3.7	3.4 ± 2.4	28.0 ± 2.2	62.7 ± 9.0	134 ± 3	5.1 ± 0.7	104 ± 3.9	9.3 ± 0.9	1.9 ± 0.2

PCO₂, partial pressure of carbon dioxide; PO₂, partial pressure of oxygen; BE, base excess; HCO₃¯, bicarbonate; SO₂, oxygen saturation; AG, anion gap. T0, immediately prior to injection of digoxin; T1-T7, 1, 2, 3, 4, 24, 48 and 72 h after digoxin administration. ^bDiffer significantly at P < 0.05 compared to pre-injection values.

ISSN: 1746-6148