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Table 4 Effect of test substances on packed cell volume (PCV) of Trypanosma congolense infected mice

From: Antitrypanosomal activity of aloin and its derivatives against Trypanosoma congolensefield isolate

Treatment Dose (mg/kg) PCV/Day of treatment
  PCV0   PCV7   PCV14
Exudate 100 47.10 ± 0.68 42.40 ± 1.07bc 45.10 ± 0.91a
200 48.30 ± 1.11 44.00 ± 1.50b 48.20 ± 0,46a
400 47.00 ± 1.21 43.60 ± 1.41b 47.60 ± 1.44a
Aloin 100 46.40 ± 1.53 40.00 ± 1.87bc 42.70 ± 1.21bc
200 46.00 ± 1.17 40.60 ± 1.22bc 43.90 ± 0.66bc
400 45.50 ± 1.50 41.70 ± 1.21bc 46.20 ± 1.34a
Aloe-emodin 100 50.20 ± 1.20 44.20 ± 1.65b 47.20 ± 0.73a
200 47.90 ± 0.60 44.30 ± 0.80b 46.10 ± 0.87a
400 47.10 ± 0.57 45.90 ± 1.45b 47.30 ± 0.73a
Rhein 100 47.10 ± 0.64 45.40 ± 0.76b 47.20 ± 0.25a
200 50.00 ± 0.65 45.80 ± 0.46b 49.30 ± 0.41a
400 50.20 ± 1,10 48.00 ± 1.15 50.40 ± 0.73a
Diminazene aceturate 28 50.10 ± 0.33 48.60 ± 0.57 50.60 ± 0.43a
Distilled water 0.1 ml 46.00 ± 0.79 42.10 ± 1.18bc 40.10 ± 1.10*
Uninfected untreated _ 50.50 ± 0.59 51.10 ± 0.66 50.80 ± 0.67
  1. Values are Mean ± SEM, N = 6, D = day, PCV0 = PCV on the day treatment commenced, SEM = standard error of mean. All superscripts indicate significance at P < 0.05 (aagainst negative control, bagainst uninfected-untreated, cagainst 28 mg/kg diminazene aceturate, *against all groups), PCV was compared with each other mainly at days 7 and 14.