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Table 3 Effect of test substances on parasitaemia level of Trypanosoma congolense infected mice

From: Antitrypanosomal activity of aloin and its derivatives against Trypanosoma congolensefield isolate

Test substance

Dose (mg/kg)

Trypanosomes/mla

ā€ƒā€‚ D0

ā€ƒā€‚ D2

ā€ƒā€‚ D4

ā€ƒā€‚ D6

ā€ƒā€ƒ D8

ā€ƒā€‚ D10

ā€ƒā€‚ D12

ā€ƒā€‚ D14

Exudate

100

7.76ā€‰Ā±ā€‰0.02

7.84ā€‰Ā±ā€‰0.06

8.00ā€‰Ā±ā€‰0.09

7.96ā€‰Ā±ā€‰0.08

7.18ā€‰Ā±ā€‰0.38

7.64ā€‰Ā±ā€‰0.12

7.76ā€‰Ā±ā€‰0.18

8.18ā€‰Ā±ā€‰0.09

200

7.50ā€‰Ā±ā€‰0.10

7.90ā€‰Ā±ā€‰0.08

7.80ā€‰Ā±ā€‰0.06

7.14ā€‰Ā±ā€‰0.24

6.06ā€‰Ā±ā€‰0.11

7.06ā€‰Ā±ā€‰0.29

7.56ā€‰Ā±ā€‰0.15

7.82ā€‰Ā±ā€‰0.15

400

7.46ā€‰Ā±ā€‰0.09

7.86ā€‰Ā±ā€‰0.10

7.90ā€‰Ā±ā€‰0.15

4.92ā€‰Ā±ā€‰1.23b

3.84ā€‰Ā±ā€‰0.90b

4.56ā€‰Ā±ā€‰1.20b

4.80ā€‰Ā±ā€‰0.15b

5.44ā€‰Ā±ā€‰0.37

Aloin

100

7.34ā€‰Ā±ā€‰0.06

7.70ā€‰Ā±ā€‰0.13

7.96ā€‰Ā±ā€‰0.08

8.07ā€‰Ā±ā€‰0.07

7.54ā€‰Ā±ā€‰0.21

7.70ā€‰Ā±ā€‰0.14

7.80ā€‰Ā±ā€‰0.18

8.19ā€‰Ā±ā€‰0.08

200

7.74ā€‰Ā±ā€‰0.05

7.94ā€‰Ā±ā€‰0.06

7.86ā€‰Ā±ā€‰0.05

7.40ā€‰Ā±ā€‰0.29

6.60ā€‰Ā±ā€‰0.32

7.10ā€‰Ā±ā€‰0.27

7.82ā€‰Ā±ā€‰0.18

7.83ā€‰Ā±ā€‰0.13

400

7.38ā€‰Ā±ā€‰0.09

7.95ā€‰Ā±ā€‰0.14

7.97ā€‰Ā±ā€‰0.11

5.24ā€‰Ā±ā€‰1.40

4.38ā€‰Ā±ā€‰1.09b

5.62ā€‰Ā±ā€‰1.50

5.98ā€‰Ā±ā€‰0.15

6.02ā€‰Ā±ā€‰0.49

Aloe-emodin

100

7.48ā€‰Ā±ā€‰0.09

7.72ā€‰Ā±ā€‰0.73

7.96ā€‰Ā±ā€‰0.05

8.14ā€‰Ā±ā€‰0.17

7.57ā€‰Ā±ā€‰0.19

7.75ā€‰Ā±ā€‰0.08

7.82ā€‰Ā±ā€‰0.17

8.20ā€‰Ā±ā€‰0.05

200

7.42ā€‰Ā±ā€‰0.07

7.92ā€‰Ā±ā€‰0.03

7.88ā€‰Ā±ā€‰0.03

7.48ā€‰Ā±ā€‰0.30

6.77ā€‰Ā±ā€‰0.27

7.36ā€‰Ā±ā€‰0.20

7.76ā€‰Ā±ā€‰0.16

7.97ā€‰Ā±ā€‰0.17

400

7.37ā€‰Ā±ā€‰0.08

7.90ā€‰Ā±ā€‰0.15

8.00ā€‰Ā±ā€‰0.13

5.38ā€‰Ā±ā€‰1.42

4.56ā€‰Ā±ā€‰1.14b

6.04ā€‰Ā±ā€‰1.52

6.74ā€‰Ā±ā€‰0.13

6.90ā€‰Ā±ā€‰0.38

Rhein

100

7.23ā€‰Ā±ā€‰0.18

7.29ā€‰Ā±ā€‰0.27

6.49ā€‰Ā±ā€‰0.30

5.58ā€‰Ā±ā€‰0.40

4.92ā€‰Ā±ā€‰1.53

4.22ā€‰Ā±ā€‰1.56

5.21ā€‰Ā±ā€‰0.37

5.57ā€‰Ā±ā€‰1.51

200

7.41ā€‰Ā±ā€‰0.08

6.97ā€‰Ā±ā€‰0.33

5.32ā€‰Ā±ā€‰1.37

5.24ā€‰Ā±ā€‰1.35

3.66ā€‰Ā±ā€‰1.51b

4.10ā€‰Ā±ā€‰0.27b

4.82ā€‰Ā±ā€‰0.18b

4.83ā€‰Ā±ā€‰0.13b

400

7.41ā€‰Ā±ā€‰0.08

7.00ā€‰Ā±ā€‰0.25

4.88ā€‰Ā±ā€‰1.28b

3.66ā€‰Ā±ā€‰1.50b

2.34ā€‰Ā±ā€‰1.44b

2.22ā€‰Ā±ā€‰1.45b

2.96ā€‰Ā±ā€‰0.33b

3.22ā€‰Ā±ā€‰0.25b

Deminazene aceturate

28

7.35ā€‰Ā±ā€‰0.08

0.00ā€‰Ā±ā€‰0.00

0.00ā€‰Ā±ā€‰0.00

0.00ā€‰Ā±ā€‰0.00

0.00ā€‰Ā±ā€‰0.00

0.00ā€‰Ā±ā€‰0.00

1.08ā€‰Ā±ā€‰1.08

1.97ā€‰Ā±ā€‰1.36

Distilled water

0.1 ml

7.43ā€‰Ā±ā€‰0.10

8.10ā€‰Ā±ā€‰0.08

8.60ā€‰Ā±ā€‰0.08

8.65ā€‰Ā±ā€‰0.13

8.71ā€‰Ā±ā€‰0.06

9.36ā€‰Ā±ā€‰0.20

8.94ā€‰Ā±ā€‰0.03

8.72ā€‰Ā±ā€‰0.34

  1. aThe antilog values of the numbers indicated in the table give the absolute number of trypanosomes/ml of blood; bSignificantly different when compared with the negative control (Pā€‰<ā€‰0.05); Values are Meanā€‰Ā±ā€‰SEM; Nā€‰=ā€‰6; Dā€‰=ā€‰day; D0ā€‰=ā€‰the day treatment commenced; SEMā€‰=ā€‰standard error of mean.