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Table 3 Effect of test substances on parasitaemia level of Trypanosoma congolense infected mice

From: Antitrypanosomal activity of aloin and its derivatives against Trypanosoma congolensefield isolate

Test substance Dose (mg/kg) Trypanosomes/mla
   D0    D2    D4    D6    D8    D10    D12    D14
Exudate 100 7.76 ± 0.02 7.84 ± 0.06 8.00 ± 0.09 7.96 ± 0.08 7.18 ± 0.38 7.64 ± 0.12 7.76 ± 0.18 8.18 ± 0.09
200 7.50 ± 0.10 7.90 ± 0.08 7.80 ± 0.06 7.14 ± 0.24 6.06 ± 0.11 7.06 ± 0.29 7.56 ± 0.15 7.82 ± 0.15
400 7.46 ± 0.09 7.86 ± 0.10 7.90 ± 0.15 4.92 ± 1.23b 3.84 ± 0.90b 4.56 ± 1.20b 4.80 ± 0.15b 5.44 ± 0.37
Aloin 100 7.34 ± 0.06 7.70 ± 0.13 7.96 ± 0.08 8.07 ± 0.07 7.54 ± 0.21 7.70 ± 0.14 7.80 ± 0.18 8.19 ± 0.08
200 7.74 ± 0.05 7.94 ± 0.06 7.86 ± 0.05 7.40 ± 0.29 6.60 ± 0.32 7.10 ± 0.27 7.82 ± 0.18 7.83 ± 0.13
400 7.38 ± 0.09 7.95 ± 0.14 7.97 ± 0.11 5.24 ± 1.40 4.38 ± 1.09b 5.62 ± 1.50 5.98 ± 0.15 6.02 ± 0.49
Aloe-emodin 100 7.48 ± 0.09 7.72 ± 0.73 7.96 ± 0.05 8.14 ± 0.17 7.57 ± 0.19 7.75 ± 0.08 7.82 ± 0.17 8.20 ± 0.05
200 7.42 ± 0.07 7.92 ± 0.03 7.88 ± 0.03 7.48 ± 0.30 6.77 ± 0.27 7.36 ± 0.20 7.76 ± 0.16 7.97 ± 0.17
400 7.37 ± 0.08 7.90 ± 0.15 8.00 ± 0.13 5.38 ± 1.42 4.56 ± 1.14b 6.04 ± 1.52 6.74 ± 0.13 6.90 ± 0.38
Rhein 100 7.23 ± 0.18 7.29 ± 0.27 6.49 ± 0.30 5.58 ± 0.40 4.92 ± 1.53 4.22 ± 1.56 5.21 ± 0.37 5.57 ± 1.51
200 7.41 ± 0.08 6.97 ± 0.33 5.32 ± 1.37 5.24 ± 1.35 3.66 ± 1.51b 4.10 ± 0.27b 4.82 ± 0.18b 4.83 ± 0.13b
400 7.41 ± 0.08 7.00 ± 0.25 4.88 ± 1.28b 3.66 ± 1.50b 2.34 ± 1.44b 2.22 ± 1.45b 2.96 ± 0.33b 3.22 ± 0.25b
Deminazene aceturate 28 7.35 ± 0.08 0.00 ± 0.00 0.00 ± 0.00 0.00 ± 0.00 0.00 ± 0.00 0.00 ± 0.00 1.08 ± 1.08 1.97 ± 1.36
Distilled water 0.1 ml 7.43 ± 0.10 8.10 ± 0.08 8.60 ± 0.08 8.65 ± 0.13 8.71 ± 0.06 9.36 ± 0.20 8.94 ± 0.03 8.72 ± 0.34
  1. aThe antilog values of the numbers indicated in the table give the absolute number of trypanosomes/ml of blood; bSignificantly different when compared with the negative control (P < 0.05); Values are Mean ± SEM; N = 6; D = day; D0 = the day treatment commenced; SEM = standard error of mean.