Table 3 Effect of test substances on parasitaemia level of Trypanosoma congolense infected mice
From: Antitrypanosomal activity of aloin and its derivatives against Trypanosoma congolensefield isolate
| Test substance | Dose (mg/kg) | Trypanosomes/mla | |||||||
|---|---|---|---|---|---|---|---|---|---|
| D0 | D2 | D4 | D6 | D8 | D10 | D12 | D14 | ||
| Exudate | 100 | 7.76 ± 0.02 | 7.84 ± 0.06 | 8.00 ± 0.09 | 7.96 ± 0.08 | 7.18 ± 0.38 | 7.64 ± 0.12 | 7.76 ± 0.18 | 8.18 ± 0.09 |
| 200 | 7.50 ± 0.10 | 7.90 ± 0.08 | 7.80 ± 0.06 | 7.14 ± 0.24 | 6.06 ± 0.11 | 7.06 ± 0.29 | 7.56 ± 0.15 | 7.82 ± 0.15 | |
| 400 | 7.46 ± 0.09 | 7.86 ± 0.10 | 7.90 ± 0.15 | 4.92 ± 1.23b | 3.84 ± 0.90b | 4.56 ± 1.20b | 4.80 ± 0.15b | 5.44 ± 0.37 | |
| Aloin | 100 | 7.34 ± 0.06 | 7.70 ± 0.13 | 7.96 ± 0.08 | 8.07 ± 0.07 | 7.54 ± 0.21 | 7.70 ± 0.14 | 7.80 ± 0.18 | 8.19 ± 0.08 |
| 200 | 7.74 ± 0.05 | 7.94 ± 0.06 | 7.86 ± 0.05 | 7.40 ± 0.29 | 6.60 ± 0.32 | 7.10 ± 0.27 | 7.82 ± 0.18 | 7.83 ± 0.13 | |
| 400 | 7.38 ± 0.09 | 7.95 ± 0.14 | 7.97 ± 0.11 | 5.24 ± 1.40 | 4.38 ± 1.09b | 5.62 ± 1.50 | 5.98 ± 0.15 | 6.02 ± 0.49 | |
| Aloe-emodin | 100 | 7.48 ± 0.09 | 7.72 ± 0.73 | 7.96 ± 0.05 | 8.14 ± 0.17 | 7.57 ± 0.19 | 7.75 ± 0.08 | 7.82 ± 0.17 | 8.20 ± 0.05 |
| 200 | 7.42 ± 0.07 | 7.92 ± 0.03 | 7.88 ± 0.03 | 7.48 ± 0.30 | 6.77 ± 0.27 | 7.36 ± 0.20 | 7.76 ± 0.16 | 7.97 ± 0.17 | |
| 400 | 7.37 ± 0.08 | 7.90 ± 0.15 | 8.00 ± 0.13 | 5.38 ± 1.42 | 4.56 ± 1.14b | 6.04 ± 1.52 | 6.74 ± 0.13 | 6.90 ± 0.38 | |
| Rhein | 100 | 7.23 ± 0.18 | 7.29 ± 0.27 | 6.49 ± 0.30 | 5.58 ± 0.40 | 4.92 ± 1.53 | 4.22 ± 1.56 | 5.21 ± 0.37 | 5.57 ± 1.51 |
| 200 | 7.41 ± 0.08 | 6.97 ± 0.33 | 5.32 ± 1.37 | 5.24 ± 1.35 | 3.66 ± 1.51b | 4.10 ± 0.27b | 4.82 ± 0.18b | 4.83 ± 0.13b | |
| 400 | 7.41 ± 0.08 | 7.00 ± 0.25 | 4.88 ± 1.28b | 3.66 ± 1.50b | 2.34 ± 1.44b | 2.22 ± 1.45b | 2.96 ± 0.33b | 3.22 ± 0.25b | |
| Deminazene aceturate | 28 | 7.35 ± 0.08 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 1.08 ± 1.08 | 1.97 ± 1.36 |
| Distilled water | 0.1 ml | 7.43 ± 0.10 | 8.10 ± 0.08 | 8.60 ± 0.08 | 8.65 ± 0.13 | 8.71 ± 0.06 | 9.36 ± 0.20 | 8.94 ± 0.03 | 8.72 ± 0.34 |