From: Antitrypanosomal activity of aloin and its derivatives against Trypanosoma congolensefield isolate
Test substance | Dose (mg/kg) | Trypanosomes/mla | |||||||
---|---|---|---|---|---|---|---|---|---|
āā D0 | āā D2 | āā D4 | āā D6 | āā D8 | āā D10 | āā D12 | āā D14 | ||
Exudate | 100 | 7.76āĀ±ā0.02 | 7.84āĀ±ā0.06 | 8.00āĀ±ā0.09 | 7.96āĀ±ā0.08 | 7.18āĀ±ā0.38 | 7.64āĀ±ā0.12 | 7.76āĀ±ā0.18 | 8.18āĀ±ā0.09 |
200 | 7.50āĀ±ā0.10 | 7.90āĀ±ā0.08 | 7.80āĀ±ā0.06 | 7.14āĀ±ā0.24 | 6.06āĀ±ā0.11 | 7.06āĀ±ā0.29 | 7.56āĀ±ā0.15 | 7.82āĀ±ā0.15 | |
400 | 7.46āĀ±ā0.09 | 7.86āĀ±ā0.10 | 7.90āĀ±ā0.15 | 4.92āĀ±ā1.23b | 3.84āĀ±ā0.90b | 4.56āĀ±ā1.20b | 4.80āĀ±ā0.15b | 5.44āĀ±ā0.37 | |
Aloin | 100 | 7.34āĀ±ā0.06 | 7.70āĀ±ā0.13 | 7.96āĀ±ā0.08 | 8.07āĀ±ā0.07 | 7.54āĀ±ā0.21 | 7.70āĀ±ā0.14 | 7.80āĀ±ā0.18 | 8.19āĀ±ā0.08 |
200 | 7.74āĀ±ā0.05 | 7.94āĀ±ā0.06 | 7.86āĀ±ā0.05 | 7.40āĀ±ā0.29 | 6.60āĀ±ā0.32 | 7.10āĀ±ā0.27 | 7.82āĀ±ā0.18 | 7.83āĀ±ā0.13 | |
400 | 7.38āĀ±ā0.09 | 7.95āĀ±ā0.14 | 7.97āĀ±ā0.11 | 5.24āĀ±ā1.40 | 4.38āĀ±ā1.09b | 5.62āĀ±ā1.50 | 5.98āĀ±ā0.15 | 6.02āĀ±ā0.49 | |
Aloe-emodin | 100 | 7.48āĀ±ā0.09 | 7.72āĀ±ā0.73 | 7.96āĀ±ā0.05 | 8.14āĀ±ā0.17 | 7.57āĀ±ā0.19 | 7.75āĀ±ā0.08 | 7.82āĀ±ā0.17 | 8.20āĀ±ā0.05 |
200 | 7.42āĀ±ā0.07 | 7.92āĀ±ā0.03 | 7.88āĀ±ā0.03 | 7.48āĀ±ā0.30 | 6.77āĀ±ā0.27 | 7.36āĀ±ā0.20 | 7.76āĀ±ā0.16 | 7.97āĀ±ā0.17 | |
400 | 7.37āĀ±ā0.08 | 7.90āĀ±ā0.15 | 8.00āĀ±ā0.13 | 5.38āĀ±ā1.42 | 4.56āĀ±ā1.14b | 6.04āĀ±ā1.52 | 6.74āĀ±ā0.13 | 6.90āĀ±ā0.38 | |
Rhein | 100 | 7.23āĀ±ā0.18 | 7.29āĀ±ā0.27 | 6.49āĀ±ā0.30 | 5.58āĀ±ā0.40 | 4.92āĀ±ā1.53 | 4.22āĀ±ā1.56 | 5.21āĀ±ā0.37 | 5.57āĀ±ā1.51 |
200 | 7.41āĀ±ā0.08 | 6.97āĀ±ā0.33 | 5.32āĀ±ā1.37 | 5.24āĀ±ā1.35 | 3.66āĀ±ā1.51b | 4.10āĀ±ā0.27b | 4.82āĀ±ā0.18b | 4.83āĀ±ā0.13b | |
400 | 7.41āĀ±ā0.08 | 7.00āĀ±ā0.25 | 4.88āĀ±ā1.28b | 3.66āĀ±ā1.50b | 2.34āĀ±ā1.44b | 2.22āĀ±ā1.45b | 2.96āĀ±ā0.33b | 3.22āĀ±ā0.25b | |
Deminazene aceturate | 28 | 7.35āĀ±ā0.08 | 0.00āĀ±ā0.00 | 0.00āĀ±ā0.00 | 0.00āĀ±ā0.00 | 0.00āĀ±ā0.00 | 0.00āĀ±ā0.00 | 1.08āĀ±ā1.08 | 1.97āĀ±ā1.36 |
Distilled water | 0.1 ml | 7.43āĀ±ā0.10 | 8.10āĀ±ā0.08 | 8.60āĀ±ā0.08 | 8.65āĀ±ā0.13 | 8.71āĀ±ā0.06 | 9.36āĀ±ā0.20 | 8.94āĀ±ā0.03 | 8.72āĀ±ā0.34 |