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Table 2 Duration (days) after which parasitaemia developed in mice inoculated with a mixture of test substances and Trypanosoma congolense infected blood

From: Antitrypanosomal activity of aloin and its derivatives against Trypanosoma congolensefield isolate

Dose of test substance mixed with 0.02 ml of infected blood Number of mice which developed infection Infection interval in days (mean ± SEM)
4.0 mg/ml E 0/5 Ni
2.0 mg/ml E 2/5 17.50 ± 0.50
0.4 mg/ml E 4/5 13.75 ± 0.48
0.1 mg/ml E 5/5 12.20 ± 0.40
4.0 mg/ml A 1/5 26.00
2.0 mg/ml A 3/5 16 ± 0.58
0.4 mg/ml A 5/5 13.40 ± 0.24
0.1 mg/ml A 5/5 11.80 ± 0.66
4.0 mg/ml AE 0/5 Ni
2.0 mg/ml AE 2/5 18.00 ± 1.00
0.4 mg/ml AE 4/5 14.00 ± 0.40
0.1 mg/ml AE 5/5 12.00 ± 0.54
4.0 mg/ml Rx 0/5 Ni
2.0 mg/ml Rx 2/5 19.50 ± 0.71
0.4 mg/ml Rx 3/5 17.00 ± 0.58
0.1 mg/ml Rx 5/5 14.20 ± 0.37
4.0 mg/ml DA 0/5 Ni
2.0 mg/ml DA 1/5 19.00
0.4 mg/ml DA 3/5 16.33 ± 0.33
0.1 mg/ml DA 5/5 13.40 ± 0.81
0.1 ml 10% DMSO 5/5 11.20 ± 0.49
  1. N = 5, Ni = no infection developed in the observation period, E = leaf exudate of Aloe gilbertii, A = aloin, AE = aloe-emodin, Rx = rhein, DA = diminazene aceturate, DMSO = dimethylsulfoxide, SEM = standard error of mean.