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Table 3 Relative mRNA concentrations of genes associated with DNA damage, DNA repair and cell cycle in the liver of Holstein cows at 3 wk antepartum and 1, 5 and 14 wk postpartum 1

From: Up-regulation of endoplasmic reticulum stress induced genes of the unfolded protein response in the liver of periparturient dairy cows

Gene2 3 wk antepartum (n = 13) 1 wk postpartum (n = 13) 5 wk postpartum (n = 13) 14 wk postpartum (n = 13)
ATM 1.00 ± 0.21a 2.29 ± 0.21b 1.94 ± 0.35ab 1.81 ± 0.26ab
BRCA1 1.00 ± 0.22 1.71 ± 0.27 1.59 ± 0.20 1.33 ± 0.23
HSBP1 1.00 ± 0.23a 3.04 ± 0.42b 2.14 ± 0.24ab 1.65 ± 0.34a
HSPA8 1.00 ± 0.24a 2.01 ± 0.24b 1.78 ± 0.23ab 1.22 ± 0.27a
MSH2 1.00 ± 0.20a 4.04 ± 0.61b 1.81 ± 0.22a 1.41 ± 0.23a
RPS9 1.00 ± 0.20a 3.68 ± 0.28c 2.23 ± 0.29b 1.64 ± 0.31ab
XRCC5 1.00 ± 0.21a 3.69 ± 0.54c 2.35 ± 0.27b 1.43 ± 0.26a
  1. 1mRNA concentrations of genes are expressed relative to the mRNA abundance at 3 wk antepartum.
  2. 2ATM = ataxia telangiectasia mutated; BRCA1 = breast cancer 1, early onset; HSBP1 = heat shock factor binding protein 1; HSPA8 = heat shock 70 kDa protein 8; MSH2 = mutS homolog 2; RPS9 = ribosomal protein S9; XRCC5 = X-ray repair cross-complementing protein 5-like.
  3. Values are means ± SEM.
  4. a,b,cMeans without common superscripts differ significantly (P < 0.05).