Up-regulation of endoplasmic reticulum stress induced genes of the unfolded protein response in the liver of periparturient dairy cows

Table 3 Relative mRNA concentrations of genes associated with DNA damage, DNA repair and cell cycle in the liver of Holstein cows at 3 wk antepartum and 1, 5 and 14 wk postpartum ¹

Gene²	3 wk antepartum (n = 13)	1 wk postpartum (n = 13)	5 wk postpartum (n = 13)	14 wk postpartum (n = 13)
ATM	1.00 ± 0.21^a	2.29 ± 0.21^b	1.94 ± 0.35^ab	1.81 ± 0.26^ab
BRCA1	1.00 ± 0.22	1.71 ± 0.27	1.59 ± 0.20	1.33 ± 0.23
HSBP1	1.00 ± 0.23^a	3.04 ± 0.42^b	2.14 ± 0.24^ab	1.65 ± 0.34^a
HSPA8	1.00 ± 0.24^a	2.01 ± 0.24^b	1.78 ± 0.23^ab	1.22 ± 0.27^a
MSH2	1.00 ± 0.20^a	4.04 ± 0.61^b	1.81 ± 0.22^a	1.41 ± 0.23^a
RPS9	1.00 ± 0.20^a	3.68 ± 0.28^c	2.23 ± 0.29^b	1.64 ± 0.31^ab
XRCC5	1.00 ± 0.21^a	3.69 ± 0.54^c	2.35 ± 0.27^b	1.43 ± 0.26^a

¹mRNA concentrations of genes are expressed relative to the mRNA abundance at 3 wk antepartum.
²ATM = ataxia telangiectasia mutated; BRCA1 = breast cancer 1, early onset; HSBP1 = heat shock factor binding protein 1; HSPA8 = heat shock 70 kDa protein 8; MSH2 = mutS homolog 2; RPS9 = ribosomal protein S9; XRCC5 = X-ray repair cross-complementing protein 5-like.
Values are means ± SEM.
^a,b,cMeans without common superscripts differ significantly (P < 0.05).

ISSN: 1746-6148