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Table 2 Relative mRNA concentrations of ER stress-induced genes in the liver of Holstein cows at 3 wk antepartum and 1, 5 and 14 wk postpartum 1

From: Up-regulation of endoplasmic reticulum stress induced genes of the unfolded protein response in the liver of periparturient dairy cows

Gene2 3 wk antepartum (n = 13) 1 wk postpartum (n = 13) 5 wk postpartum (n = 13) 14 wk postpartum (n = 13)
ATF4 1.00 ± 0.25a 3.14 ± 0.25c 2.08 ± 0.26b 1.65 ± 0.24b
BAK1 1.00 ± 0.29a 2.10 ± 0.30b 1.56 ± 0.29ab 1.59 ± 0.28ab
BAX 1.00 ± 0.36a 3.02 ± 0.39b 1.98 ± 0.35ab 1.52 ± 0.35a
CASP3 1.00 ± 0.31a 2.54 ± 0.27b 2.07 ± 0.26b 1.71 ± 0.26ab
CASP8 1.00 ± 0.25a 2.48 ± 0.24b 1.88 ± 0.23ab 1.73 ± 0.23ab
CASP9 1.00 ± 0.37a 2.45 ± 0.35b 1.89 ± 0.34ab 1.84 ± 0.36ab
DDIT3 1.00 ± 0.17a 1.86 ± 0.17b 1.58 ± 0.17ab 1.41 ± 0.17ab
DNAJC3 1.00 ± 0.15a 1.89 ± 0.17b 1.49 ± 0.17ab 1.43 ± 0.15ab
EDEM1 1.00 ± 0.21a 1.70 ± 0.21b 1.69 ± 0.20b 1.25 ± 0.22ab
HERPUD1 1.00 ± 0.45a 3.96 ± 0.37b 2.27 ± 0.43a 1.66 ± 0.38a
HSPA5 1.00 ± 0.29a 2.74 ± 0.27b 1.64 ± 0.26a 1.41 ± 0.24a
PDIA4 1.00 ± 0.25a 1.92 ± 0.28b 1.34 ± 0.24ab 1.23 ± 0.25ab
WARS 1.00 ± 0.35a 2.03 ± 0.31ab 2.31 ± 0.29b 1.93 ± 0.30ab
XBP1 (unspliced) 1.00 ± 0.25a 3.14 ± 0.25c 2.08 ± 0.26b 1.65 ± 0.24b
  1. 1mRNA concentrations of genes are expressed relative to the mRNA abundance at 3 wk antepartum.
  2. 2Abbreviations of gene names: see Table 1.
  3. Values are means ± SEM.
  4. a,b,cMeans without common superscripts differ significantly (P < 0.05).
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