Up-regulation of endoplasmic reticulum stress induced genes of the unfolded protein response in the liver of periparturient dairy cows

Table 2 Relative mRNA concentrations of ER stress-induced genes in the liver of Holstein cows at 3 wk antepartum and 1, 5 and 14 wk postpartum ¹

Gene²	3 wk antepartum (n = 13)	1 wk postpartum (n = 13)	5 wk postpartum (n = 13)	14 wk postpartum (n = 13)
ATF4	1.00 ± 0.25^a	3.14 ± 0.25^c	2.08 ± 0.26^b	1.65 ± 0.24^b
BAK1	1.00 ± 0.29^a	2.10 ± 0.30^b	1.56 ± 0.29^ab	1.59 ± 0.28^ab
BAX	1.00 ± 0.36^a	3.02 ± 0.39^b	1.98 ± 0.35^ab	1.52 ± 0.35^a
CASP3	1.00 ± 0.31^a	2.54 ± 0.27^b	2.07 ± 0.26^b	1.71 ± 0.26^ab
CASP8	1.00 ± 0.25^a	2.48 ± 0.24^b	1.88 ± 0.23^ab	1.73 ± 0.23^ab
CASP9	1.00 ± 0.37^a	2.45 ± 0.35^b	1.89 ± 0.34^ab	1.84 ± 0.36^ab
DDIT3	1.00 ± 0.17^a	1.86 ± 0.17^b	1.58 ± 0.17^ab	1.41 ± 0.17^ab
DNAJC3	1.00 ± 0.15^a	1.89 ± 0.17^b	1.49 ± 0.17^ab	1.43 ± 0.15^ab
EDEM1	1.00 ± 0.21^a	1.70 ± 0.21^b	1.69 ± 0.20^b	1.25 ± 0.22^ab
HERPUD1	1.00 ± 0.45^a	3.96 ± 0.37^b	2.27 ± 0.43^a	1.66 ± 0.38^a
HSPA5	1.00 ± 0.29^a	2.74 ± 0.27^b	1.64 ± 0.26^a	1.41 ± 0.24^a
PDIA4	1.00 ± 0.25^a	1.92 ± 0.28^b	1.34 ± 0.24^ab	1.23 ± 0.25^ab
WARS	1.00 ± 0.35^a	2.03 ± 0.31^ab	2.31 ± 0.29^b	1.93 ± 0.30^ab
XBP1 (unspliced)	1.00 ± 0.25^a	3.14 ± 0.25^c	2.08 ± 0.26^b	1.65 ± 0.24^b

¹mRNA concentrations of genes are expressed relative to the mRNA abundance at 3 wk antepartum.
²Abbreviations of gene names: see Table 1.
Values are means ± SEM.
^a,b,cMeans without common superscripts differ significantly (P < 0.05).

ISSN: 1746-6148