TY - JOUR AU - Yu, Ying AU - Cai, Xuehui AU - Wang, Gang AU - Kong, Ning AU - Liu, Yonggang AU - Xiao, Yihong AU - Zhang, Chong AU - Mu, Yang AU - Xiao, Shuqi AU - Zhao, Qin AU - Wang, Chengbao AU - Zhang, Gaiping AU - Hiscox, Julian A. AU - Zhou, En-Min PY - 2014 DA - 2014/02/08 TI - Anti-idiotypic antibodies reduce efficacy of the attenuated vaccine against highly pathogenic PRRSV challenge JO - BMC Veterinary Research SP - 39 VL - 10 IS - 1 AB - The inability of current vaccines to provide effective protection against porcine reproductive and respiratory syndrome virus (PRRSV) infection is not fully understood. One of the reasons might be the presence of anti-idiotypic antibodies (Ab2s) to the envelope glycoprotein GP5 induced by PRRSV infection since our previous studies demonstrated the presence of auto-Ab2s (aAb2s) in pigs infected with PRRSV. To test this hypothesis, PRRSV negative piglets were injected with a monoclonal Ab2 (Mab2-5G2) and aAb2s that are specific for anti-GP5 antibody, vaccinated with the attenuated PRRSV vaccine CH-1R and then challenged with the highly pathogenic PRRSV HuN4 strain. The animals were evaluated for clinical signs, pathological changes of the thymus and lungs, viremia, levels of serum antibodies and cytokines. SN - 1746-6148 UR - https://doi.org/10.1186/1746-6148-10-39 DO - 10.1186/1746-6148-10-39 ID - Yu2014 ER -