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Table 6 Adverse events

From: GS-9219/VDC-1101 - a prodrug of the acyclic nucleotide PMEG has antitumor activity inspontaneous canine multiple myeloma

  Grade 1 Grade 2 Grade 3 Grade 4 Grade 5
Hypercalcemia 2*     
Hypomagnesemia 1     
Hypercholesterolemia 6     
Hyperchloremia 1     
Increased liver enzymes 5 2 1   
Hypokalemia 3     
Hyponatremia 3     
Hypochloremia 3     
Neutropenia   2 1 1**  
Increased creatinine   1    
Increased BUN 1     
Hypophosphatemia 1     
Lethargy 1     
Anorexia 1     
Diarrhea 1     
Pulmonary      2
Dermatopathy 2 4    
  1. *Associated with disease progression in 1 patient.
  2. **Neutropenia existed prior to treatment in this patient.