Stringent Complete Response (sCR) | Normalization of paraprotein |
Disappearance of any soft-tissue plasmacytomas | |
<5% plasma cells in bone marrow | |
Absence of clonal cells in bone marrow by PARR | |
Complete Response (CR) | Same as above, without clonality criterion |
Partial Response (PR) | >50% reduction in paraprotein from baseline |
>50% reduction in bone marrow plasma cells | |
>50% reduction in soft-tissue plasmacytomas, if present | |
Stable Disease (SD) | Not meeting criteria for CR, PR or PD |
Progressive Disease (PD) | Increase of 25% from lowest response value in: |
Serum paraprotein | |
Bone marrow plasma cell percentage (exceeding 10%) | |
Definite development of new bone or soft-tissue lesions | |
Definite increase in size of existing bone or soft-tissue lesions | |
Development of hypercalcemia not attributable to another cause |