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Table 1 Antiproliferative activity of VDC-1101 and its metabolites in human multiple myeloma cell lines

From: GS-9219/VDC-1101 - a prodrug of the acyclic nucleotide PMEG has antitumor activity inspontaneous canine multiple myeloma

  Calculated IC50(μM)
  H-929 RPMI-8226 U-266
PMEG 1.9 ± 0.6 0.2 ± 0.04 1.0 ± 0.3
cPrPMEDAP 1.8 ± 0.5 0.2 ± 0.06 0.7 ± 0.2
VDC-1101 0.6 ± 0.2 0.34 ± 0.05 0.6 ± 0.2