Translational medicine in veterinary and human hepatology. In HPC biology inter-species differences and similarities can be found. When reviewing HPC markers, niche characteristics and HPC response in health and disease, dogs share many similarities with man. Furthermore, dogs can bridge the gap between experimental rodent studies and human clinical application. Human medicine could benefit from its canine counterpart by appreciating the dog as a target species as well as a large animal model for the development of new therapies.