Application of hepatic progenitor cells in regenerative medicine. Schematic representation of the potential use of hepatic progenitor cells in veterinary medicine. In vivo targeting of a patient’s endogenous HPC population with small molecules would be the most elegant approach. Another option is ex vivo expansion of HPCs in culture, potential differentiation into hepatocytes and subsequent use in clinical cell transplantation. Upon differentiation HPCs can also be used for disease modeling. For example, by culturing HPCs from a patient with an inborn error of metabolism it is possible to study mechanisms of disease and to perform drug discovery screens.