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Table 1 Conserved and non-conserved amino acid substitutions in feline pancreatic GK

From: Cloning and characterization of feline islet glucokinase

Position

Amino acid residue

 

Feline GK

Mammalian GKs

16

Ala

Val

22

Asp

Glu

28

Ala

Glu

35

Trp

Ser (R) or Arg (P)

42

Ala

Asp

219

Arg

Gln

239

His

Gln

276

Val

Met (R) or Leu (P)

280

Asn

Ser

282

Leu

Ala

317

Arg

His

361

Ala

Val (R) or Thr (P)

380

Tyr

His

383

Ala

Ser

426

Ile

Ser

  1. Alignments performed using human, chimpanzee, rat, and mouse GKs.
  2. Conserved substitutions are shown in normal text.
  3. Non-conserved substitutions are shown in bold text.
  4. R = rodents (rat and mouse).
  5. P = primates (human and chimpanzee).
  6. This residue is Ala in rat, human, and chimpanzee; Val in mouse.