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Table 1 Comparison of gross and histopathological lesion frequency in CTRL and INOC groups

From: Confirmation that “Brachyspira hampsonii” clade I (Canadian strain 30599) causes mucohemorrhagic diarrhea and colitis in experimentally infected pigs

   Pvalue
Description   CTRL (n = 6) INOC (n = 11) INOC (with MHD) (n = 9) INOC vs. CTRL INOC (with MHD) vs. CTRL
Gross pathology frequency*      
  Proximal colon 1/6 8/11 8/9 0.04 0.01
  Apex colon 0/6 9/11 9/9 <0.01 <0.001
  Distal colon 0/6 7/11 7/9 0.02 <0.01
  Cecum 1/6 6/11 5/9 ns ns
  Rectum 0/6 5/11 5/9 0.08 0.04
Histopathologic lesion frequency**     
  Colonic inflammation 0/6 9/11 9/9 <0.01 <0.001
  Colonic necrosis 0/6 9/11 9/9 <0.01 <0.001
  Cecal inflammation 0/6 6/11 6/9 0.04 0.001
  Cecal necrosis 0/6 3/11 3/9 ns 0.02
  Colonic spirochetes 0/6 8/11 8/9 <0.01 0.001
  1. *Gross lesions include mucosal edema, hyperemia, congestion, with multifocal to diffuse mucofibrinonecrotic exudate.
  2. **Histopathological lesions and colonic spirochete scores graded 0 to 3 reflecting negative, mild, moderate and severe inflammation or necrosis. Scores greater than 1 were considered lesional.