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Table 1 Neutralizing antibody titers of PRRSV LV strain in mice immunized with different DNA vaccines

From: Construction and immunogenicity of a DNA vaccine coexpressing GP3 and GP5 of genotype-I porcine reproductive and respiratory syndrome virus

Immunized groups 7 dpi 14 dpi 28 dpi 42 dpi
pVAX1-EU-ORF3 <2 4.6 ± 0.22 7.3 ± 0.68 6.8 ± 0.23
pVAX1-EU-ORF5 <2 6.4 ± 0.32 10.9 ± 0.97 16.3 ± 1.45
pVAX1-EU-ORF3-ORF5 <2 8.5 ± 0.65 14.8 ± 1.28 21.1 ± 2.03
pVAX1 <2 <2 <2 <2
PBS <2 <2 <2 <2
  1. Virus-neutralizing (VN) antibody titers in mice after vaccination for different groups. Serum samples (n = 8) were collected at various time-points. PRRSV-specific neutralizing antibodies were detected by a virus neutralizing assay with two-fold serial dilutions. The VN titers were expressed as the reciprocal of the highest serum dilution in which no CPE was observed.