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Table 1 Neutralizing antibody titers of PRRSV LV strain in mice immunized with different DNA vaccines

From: Construction and immunogenicity of a DNA vaccine coexpressing GP3 and GP5 of genotype-I porcine reproductive and respiratory syndrome virus

Immunized groups

7 dpi

14 dpi

28 dpi

42 dpi

pVAX1-EU-ORF3

<2

4.6 ± 0.22

7.3 ± 0.68

6.8 ± 0.23

pVAX1-EU-ORF5

<2

6.4 ± 0.32

10.9 ± 0.97

16.3 ± 1.45

pVAX1-EU-ORF3-ORF5

<2

8.5 ± 0.65

14.8 ± 1.28

21.1 ± 2.03

pVAX1

<2

<2

<2

<2

PBS

<2

<2

<2

<2

  1. Virus-neutralizing (VN) antibody titers in mice after vaccination for different groups. Serum samples (n = 8) were collected at various time-points. PRRSV-specific neutralizing antibodies were detected by a virus neutralizing assay with two-fold serial dilutions. The VN titers were expressed as the reciprocal of the highest serum dilution in which no CPE was observed.